The Bonn site of the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn are leading contributors.
Brain
Continued high use of marijuana by the nation's eighth, 10th and 12th graders combined with a drop in perceptions of its potential harms was revealed in this year's Monitoring the Future survey, an annual survey of eighth, 10th, and 12th-graders conducted by researchers at the University of Michigan. The survey was carried out in classrooms around the country earlier this year, under a grant from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health.
LA JOLLA, Calif., December 19, 2012 – Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is untreatable and fatal. Nerve cells in the spinal cord die, eventually taking away a person's ability to move or even breathe. A consortium of ALS researchers at multiple institutions, including Sanford-Burnham Medical Research Institute, Brigham and Women's Hospital, and the University of Massachusetts Medical School, tested transplanted neural stem cells as a treatment for the disease.
(Embargoed) CHAPEL HILL, N.C. – Results of a clinical trial that began in 2001 show that a gene therapy cocktail conveyed into the brain by a molecular special delivery vehicle may help extend the lives of children with Canavan disease, a rare and fatal neurodegenerative disorder.
A report of the trial appears in the Dec. 19, 2012 online edition of the journal Science Translational Medicine.
Boston – Results from eleven independent ALS (Lou Gehrig's Disease) research studies are giving hope to the ALS community – showing for the first time that the disease may be treatable by targeting new mechanisms revealed by neural stem cell-based studies. A decade of research conducted at multiple institutions, shows that when neural stem cells were transplanted into multi-levels of the spinal cord of a mouse model with familial ALS, disease onset and progression slowed, motor and breathing function improved and treated mice survived three to four times longer than untreated mice.
Our eyes may be our window to the world, but how do we make sense of the thousands of images that flood our retinas each day? Scientists at the University of California, Berkeley, have found that the brain is wired to put in order all the categories of objects and actions that we see. They have created the first interactive map of how the brain organizes these groupings.
The result – achieved through computational models of brain imaging data collected while the subjects watched hours of movie clips – is what researchers call "a continuous semantic space."
WORCESTER, MA — An international team of researchers from the University of Massachusetts Medical School, the University of Bonn and the Center for Advanced European Studies and Research in Germany have shown that a well-known immune and inflammatory process plays an important role in the pathology of Alzheimer's disease. This process, which results in the mature production of the pro-inflammatory cytokine called interleukin-1 beta (IL-1B) and is involved in the body's defense against infection, has also been established as a clinical target for rheumatoid arthritis.
The number of Alzheimer's patients will continue to dramatically increase in the next several decades. Various teams of researchers worldwide are feverishly investigating precisely how the illness develops. A team of scientists under the guidance of the University of Bonn and University of Massachusetts (USA) and with the participation of the German Center for Neurodegenerative Diseases have discovered a new signaling pathway in mice which is involved in the development of chronic inflammation which causes nerve cells in the brain to malfunction and die off.
Experiencing rejection not only affects how we think and feel — over the long-term it can also influence our physical and mental health. New research suggests that when rejection comes in the form of discrimination, people respond with a pattern of thoughts, behaviors, and physiological responses that may contribute to overall health disparities.
"Humans can recognize thousands of categories. Given the limited size of the human brain, it seems unreasonable to expect that every category is represented in a distinct brain area," says first author Alex Huth, a graduate student working in Dr. Jack Gallant's laboratory at the University of California, Berkeley.
The authors proposed that perhaps a more efficient way for the brain to represent object and action categories would be to organize them into a continuous space that reflects the similarity between categories.
After conducting the largest online intelligence study on record, a Western University-led research team has concluded that the notion of measuring one's intelligence quotient or IQ by a singular, standardized test is highly misleading.
SAN ANTONIO (Dec. 19, 2012) — Given that epilepsy impacts more than 2 million Americans, there is a pressing need for new therapies to prevent this disabling neurological disorder. New findings from the neuroscience laboratory of Mark S. Shapiro, Ph.D., at The University of Texas Health Science Center at San Antonio, published Dec. 20 in the high-impact scientific journal, Neuron, may provide hope.
More than a century after it was first identified, Harvard scientists are shedding new light on a little-understood neural feedback mechanism that may play a key role in how the olfactory system works in the brain.
Finding the next Barack Obama or Warren Buffett might be as simple as looking at who attracts the most eyes in a crowd, a new University of British Columbia study finds.
For the study, which used eye-tracking technology, participants who observed groups of strangers were able to accurately predict who would emerge as leader of the group in 120 seconds or less.
Male birds use their song to dupe females they have just met by pretending they are in excellent physical condition.
Just as some men try to cast themselves in a better light when they approach would-be dates, so male birds in poor condition seek to portray that they are fitter than they really are. But males do not even try to deceive their long-term partners, who are able to establish the true condition of the male by their song.