The results of the largest genetic study on migraine thus far were published online in the journal Nature Genetics today, June 20. The study was based on DNA samples of 375,000 European, American and Australian participants. Almost 60,000 of them suffer from migraine.
Body
Mapping the molecular structure where medicine goes to work is a crucial step toward drug discovery against deadly diseases.
Researchers at Michigan State University have taken that critical first step by providing a crystal structure of the extracellular domain, or ECD, of ZIP4 - the exclusive protein responsible for the uptake of zinc from food. The ZIP family consists of thousands of zinc/iron transporter proteins, and this work represents the first-ever structural information of the ZIP family at the atomic level.
Chronic myeloid leukemia (CML) develops through chromosomal alterations in blood-forming cells of the bone marrow and usually occurs in older persons. Around 20 percent of adults diagnosed with leukemia suffer from this type of blood cancer. The protein Gab2 works as an enhancer of cancer-causing signals and is often present in larger quantities in CML cells than in healthy cells. In two studies, Freiburg researchers have made new discoveries concerning the relationship between CML and Gab2 and drugs that can break a particular resistance to Gab2 in CML cells. The team, including Dr.
BOSTON -- Surgery to remove a cancerous kidney can often lengthen the lives of patients receiving targeted therapy for metastatic kidney cancer, but only about three in ten such patients undergo the procedure, according to a new study by researchers at Dana-Farber Cancer Institute and Brigham and Women's Hospital.
CLEMSON, South Carolina -- Clemson University scientists Paul Leonard and Rob Baldwin are part of a collaborative study on how rising sea levels and increased urbanization -- both now and in the future -- are joining forces to fragment habitat connectivity across the region.
Leonard, Baldwin and four other co-authors contributed to the paper, "Landscape Connectivity Losses Due to Sea Level Rise and Land Use Change," about wildlife habitat connectivity in the Southeast that has been published in the journal Animal Conservation.
More gay and bisexual men than ever are getting tested for HIV, according to new data from the National Gay Men's Sex Survey [1]. The survey is the largest of its kind in the UK and sheds light on the sexual health of men who have sex with men.
The survey found that 77% of gay and bisexual men have been tested for HIV, more than in surveys from previous years (in 2010, this stood at 72%). Over half (55%) of gay and bisexual men had been tested in the past 12 months, compared to 36% in the 2010 survey. [2]
DURHAM, N.C. -- DNA molecules don't just code our genetic instructions. They can also conduct electricity and self-assemble into well-defined shapes, making them potential candidates for building low-cost nanoelectronic devices.
A team of researchers from Duke University and Arizona State University has shown how specific DNA sequences can turn these spiral-shaped molecules into electron "highways," allowing electricity to more easily flow through the strand.
Researchers have identified a new signaling pathway that helps cancer cells cope with the lack of oxygen found inside tumors. These are the results of a study published in Nature Cell Biology on June 20, and led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center, Princess Margaret Cancer Center, the University of Toronto, Harvard Medical School and Oxford University.
Retinas from our earliest vertebrate ancestors had cone-like photoreceptors, presumably allowing them to see in daylight, but little ability to see at night. Then, millions of years ago in the Mesozoic era, and in relatively short order, mammals emerged that had retinas with predominantly rod photoreceptors, allowing for them to see at night perhaps to hunt for food while their dinosaur predators were dozing. Now a new study led by researchers the National Eye Institute suggests how the genesis of rod photoreceptors may have occurred to give rise to nocturnal mammals.
Parents of young children diagnosed with autism spectrum disorder (ASD) may experience significant difficulties in discussing treatment options with the child's pediatrician, according to new research. Among the barriers are problems with communication, physicians' lack of knowledge about specific ASD treatments and community resources, and uncertainty about the pediatrician's role in making treatment recommendations for a child with ASD.
Invasive insects and pathogens could be a multi-billion- dollar threat to global agriculture and developing countries may be the biggest target, according to a team of international researchers.
DALLAS - June 20, 2016 - The heart is the only muscle that contracts and relaxes continuously over a lifetime to pump oxygen-rich blood to the body's organs. Researchers at UT Southwestern Medical Center now have identified a previously unrecognized enzyme that could optimize contraction and lead to new strategies to treat heart failure.
CHAPEL HILL, NC - When we smoke cigarettes, dozens of genes important for immune defense are altered in the epithelial cells that line the respiratory tract. Several of these changes likely increase the risk of bacterial infections, viruses, and inflammation. Now, UNC School of Medicine scientists report that vaping electronic cigarettes alters those same genes and hundreds more that are important for immune defense in the upper airway.
RIVERSIDE, Calif. -- A species of wasp that is a natural enemy of a wood-boring beetle that kills black locust trees has been rediscovered, more than 100 years after the last wasp of this species was found.
Children who often go hungry have a greater risk of developing impulse control problems and engaging in violence, according to new UT Dallas research.
The study, published in the International Journal of Environmental Research and Public Health, found that people who experienced frequent hunger as kids were more than twice as likely to exhibit impulsivity and injure others intentionally as adolescents and adults.