A team of Russian scientists from Moscow Institute of Physics and Technology (MIPT), the N. D. Zelinsky Institute of Organic Chemistry (RAS), the Institute of Developmental Biology (RAS), and the Institute of Cell Biophysics (RAS) proposed an efficient approach to a novel agents with anticancer activity. A synthesis of these compounds is based on compounds extracted from parsley and dill seeds. The results of the study have been published in the Journal of Natural Products.
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For cancer therapy, treatment resistance poses a major hurdle. Even aggressive treatments such as immunotherapies or nanomedicines may fail to eliminate all cancer cells, allowing new mutations to develop that may cause relapse.
The current threshold for pre-emptive surgery to remove the ovaries and fallopian tubes of women aged 40+ at high risk of developing ovarian cancer should be halved, concludes research published online in the Journal of Medical Genetics.
This would not only extend the lives of more women, but would be very cost effective, and help to compensate for the current lack of a reliable test to screen for the disease, suggest the researchers.
PISCATAWAY, NJ - Misuse of prescription pain medications remains a major public health problem -- but programs to prevent it may be underused, according to a study in the July issue of the Journal of Studies on Alcohol and Drugs.
The study comes out of Maine, one of the U.S. states hardest hit by the "epidemic" of prescription painkiller and heroin abuse. Researchers say that although there have been some positive trends recently, there are also troubling ones.
Stable flies and house flies are a concern in livestock and poultry farming because they can transmit harmful pathogens, and animals can harm themselves while trying to avoid bites from the flies. Researchers at the University of Florida found that a commercial formulation of the entomopathogenic fungus Metarhizium brunneum was effective at reducing house fly and stable fly egg-laying and inhibiting house fly development. Formulations of another fungus called Beauveria bassiana were also found to be effective, albeit less so.
Rising sea temperatures in the Mediterranean are encouraging alien lionfish species to invade and colonise new territories with potentially serious ecological and socioeconomic impacts.
Evidence collated from divers and fishermen reveals that in the space of a year, the poisonous predators have colonised Cyprus - and these may be at the vanguard of a pan-Atlantic Ocean invasion following the widening and deepening of the Suez Canal.
Biologists from Queen Mary University of London (QMUL) have discovered that the evolutionary history of a hormone responsible for sexual maturity in humans is written in the genes of the humble starfish.
Scientists at Emory Vaccine Center, in collaboration with investigators from Thailand, have found that people infected with dengue virus develop antibodies that cross-react with Zika virus.
Some of these antibodies have the potential to neutralize Zika virus - possibly providing immune protection. At the same time, in laboratory experiments, antibodies against dengue could enhance Zika virus infection of human cells.
The results are scheduled for publication on Monday, June 27 in PNAS.
(Vienna, 23 June 2016) Four new papers, co-published by an international consortium of biomedical researchers, mark the feasibility of epigenetic analysis for clinical diagnostics and precision medicine. Epigenetic analysis addresses key limitations of genetic testing, helping to ensure that patients are accurately diagnosed and treated with the right drug at the right time.
A team of scientists has uncovered the global, evolving, and historic make-up of Plasmodium vivax, one of the five species of malaria that infect humans. The research, which links the spread of the parasite back to colonial seafaring, among other phenomena, underscores the challenges health experts face in controlling the parasite.
Plasmodium vivax (P. vivax) parasites, which cause a debilitating form of malaria, are yielding their secrets to an international team of researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. In the largest such effort to date, the team determined complete genomes of nearly 200 P. vivax strains that recently infected people in eight countries. Comparative analysis showed the parasites clustered into four genetically distinct populations that provide insights into the movement of P.
BOSTON (Embargoed until 11 AM EDT, June 27, 2016)--Blood levels of seafood and plant-based omega-3 fatty acids are moderately associated with a lower risk of dying from heart attacks, according to a new epidemiological study, published today in JAMA Internal Medicine, led by Liana C. Del Gobbo, Ph.D., a postdoctoral research fellow in the division of cardiovascular medicine at Stanford University School of Medicine and senior author Dariush Mozaffarian, M.D., Dr.P.H., dean of the Friedman School of Nutrition Science and Policy at Tufts University in Boston.
New national data suggest lesbian, gay and bisexual adults were more likely to report impaired physical and mental health and heavy drinking and smoking, which may be the result of stressors they experience because of discrimination, according to an article published online by JAMA Internal Medicine.
For the first time, the 2013 and 2014 National Health Interview Survey (NHIS), one of the nation's leading health surveys, included a question on sexual orientation.
Access and use of health care resources in Sweden is equitable and affordable and the management of those resources is well developed.
Still, low socioeconomic status was associated with an increased risk of death for patients with type 2 diabetes from all causes, cardiovascular disease and diabetes-related mortality, as well as a less pronounced increased risk of cancer death, according to an article published online by JAMA Internal Medicine.
(PHILADELPHIA) -- About 5.7 million Americans have heart failure, half of whom will die from the disease within 5 years, according to the Centers for Disease Control and Prevention (CDC). Two processes help drive the disease: a weakened heart muscle that is less able to pump, and the death of heart cells that irreparably damage the heart. Beta-blockers, commonly used to treat heart disease, work by blocking the beta-adrenergic receptors in the heart, saving heart cells from cell death.