A new study shows that an important drug used in the treatment of malignant melanoma has little effect on the melanoma cells themselves. Instead, it activates immune-system cells to fight the disease.
The drug, called interferon alpha (IFNa), is used to clean up microscopic tumor cells that may remain in the body following surgery for the disease. It is the only drug approved for this purpose.
According to a study in Evolution, resistance to certain infectious diseases may be passed genetically from parent to child. The genetic resistance may be beneficial to families as those with the gene are both unlikely to suffer from disease and unlikely to carry the disease home. Paul Schliekelman, author of the study, says the research was inspired by personal experience after catching stomach flus from his daughter three times over a six-month period.
In work that could one day help prevent millions of dollars in economic losses for seaside communities, MIT chemists have demonstrated how tiny marine organisms likely produce the red tide toxin that periodically shuts down U.S. beaches and shellfish beds.
In the Aug. 31 cover story of Science, the MIT team describes an elegant method for synthesizing the lethal components of red tides. The researchers believe their method approximates the synthesis used by algae, a reaction that chemists have tried for decades to replicate, without success.
The organs that produce sperm also may make it easier for mutations to pass to offspring, USC biologists say. The testes in humans may act as mutation multipliers that raise the odds of passing improved DNA to offspring – but that can also backfire by increasing the frequency of certain diseases.
The new theory is part of a study, appearing in PLOS Biology, that tries to explain the puzzlingly high frequency of Apert syndrome, a genetic cranial deformity found in approximately one out of every 70,000 newborns.
A new study has identified a regionally-specific distribution of aluminium in breast tissue which may have implications for the cause of breast cancer.
Scientists have found that the aluminium content of breast tissue and breast tissue fat was significantly higher in the outer regions of the breast, in close proximity to the area where there would be the highest density of antiperspirant.
University of Arkansas researchers have found a simple, inexpensive way to create a nanowire coating on the surface of biocompatible titanium that can be used to create more effective surfaces for hip replacement, dental reconstruction and vascular stenting. Further, the material can easily be sterilized using ultraviolet light and water or using ethanol, making it useful in hospital settings and meat-processing plants
Dietary restrictions or other strategies that limit fat formation might make pancreatic cell transplants more effective, UT Southwestern Medical Center researchers report.
Using animal models, the researchers discovered that pancreatic islet cells transplanted into the liver fail not only because of immune rejection, but also because of overexposure to toxic fats that are synthesized by the surrounding liver cells and flood the pancreatic transplants. Their findings appear in the September issue of the journal Diabetes.
Genetically modified wheat hasn’t yet been introduced into the U.S. market. When that happens, public acceptance of the product may depend on what people know about it. Currently, they don’t know much.
People who live to 100 or more are known to have just as many—and sometimes even more—harmful gene variants compared with younger people. Now, scientists at the Albert Einstein College of Medicine of Yeshiva University have discovered the secret behind this paradox: favorable “longevity” genes that protect very old people from the bad genes’ harmful effects. The novel method used by the researchers could lead to new drugs to protect against age-related diseases.
The diverse and complex female endocrine disorder polycystic ovary syndrome (PCOS), which affects 1 in 15 women worldwide, is a major economic health burden that is likely to expand together with obesity, conclude authors of a Seminar in this week’s edition of The Lancet. Dr Theresa Hickey and Prof Robert Norman, University of Adelaide, Australia, and colleagues, reviewed published literature on PCOS up to November 2006 to prepare the Seminar.
A collaborative team of scientists reported findings today demonstrating the presence of Marburg virus RNA genome and antibodies in a common species of African fruit bat (Rousettus aegyptiacus).
Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death. Dysregulation of protein phosphorylation plays a major role in many diseases such as cancer and neurodegenerative disorders. In addition, the elucidation of many kinase cascades has proved pivotal for understanding and manipulating cellular behaviour in a variety of divergent eukaryotes.
Analysis of the chemical make up of two asteroids in the outer asteroid belt has thrown the classification system for these small bodies, which orbit between Mars and Jupiter, into disorder.
Dr Rene Duffard, said, “We appear to have detected basalt on the surface of these asteroids, which is very unusual for this part of the asteroid belt. We do not know whether we have discovered two basaltic asteroids with a very particular and previously unseen mineralogical composition or two objects of non basaltic nature that have to be included in a totally new taxonomic class.”
Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have shown that the genetic defect that causes Cockayne Syndrome affects a key function of the cell – the transcription of genes coding for ribosomal RNA.
Cockayne Syndrome is a recessively inherited disorder that belongs to a group of diseases in which defects in one of the numerous DNA repair systems lead to non-functioning proteins and, thus, to severe health impairments. These disorders also include, for example, Xeroderma pigmentosum and a type of hereditary bowel cancer.
National movements campaigning against genetic engineering are helping to democratise the EU. That was the result of a recently completed Austrian Science Fund FWF project led by an independent researcher. According to the study's results, the almost simultaneous mobilisation of national populations reinforces public protest at a European level. The project therefore provides an optimistic outlook for the growing influence of the general population on EU decision-making processes.