The pathogenic mechanisms implicated in the failure of intestinal barrier in cirrhosis have not been fully elucidated as yet and remains to be investigated.
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Apoptosis is a programmed, active, highly selective mechanism of cell death. Abnormal regulation of apoptosis can lead to disorders such as cancer. The field of apoptosis research has undergone an explosion of new knowledge over the past decade. Nuclear magnetic resonance spectroscopy is a non-destructive and non-invasive technique that can provide complete structural analysis of a wide range of organic molecules in complex mixtures. This technique can be used to detect the metabolite alteration of apoptosis.
The incidence of tuberculosis is increasing. Lymphadenopathy is the most common manifestation of abdominal tuberculosis and may, in up to 55% of cases without other evidence of abdominal involvement, be easily confused with lymphomas involving abdominal lymph nodes. Clinical and radiologic differentiation between the two can be challenging. A comparison of CT findings in tuberculosis and lymphoma of the mesenteric lymph nodes has not been reported.
Chicago, IL – Leading experts in the study of hair cells and hearing loss will discuss state-of-the art developments in determining the genetic and environmental factors that cause Age-Related Hearing Impairment (ARHI) at the 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO, in Chicago, IL.
p53-impaired tumors may be particularly suitable to parvovirus H-1-induced therapy. Although the p53 deficiency in tumors may induce resistance to chemotherapeutic agents, this will not affect the tumor cell susceptibility to H-1 PV-induced oncolytic infections. The parvovirus H-1 may also overcome other tumor resistance mechanisms developed in these tumor entities. So H-1 PV is a suitable agent to circumvent the resistance of p53-negative human hepatocellular carcinoma (HCC) cells to genotoxic agents, and enhances the apoptotic process which is dependent on functional PML.
Apoptosis resistance has been shown to contribute to the development of different cancer entities, such as colorectal carcinoma (CRC). Moreover, apoptosis resistance of carcinoma cells provides an explanation for low response rates in patients with advanced cancer receiving chemotherapy. Thus, new treatment options to sensitize carcinoma cells to apoptosis induction are needed. It has been previously shown that anti-apoptotic Bcl-2 proteins, such as Bcl-xL and Mcl-1, are expressed in CRC.
The most popular treatment for H pylori is triple therapy but resistance to Clarithromycin is reducing its effectiveness. Courses using four drugs have been known to be more successful but are used less popular because of their side-effects. While, what is the best way for treating H pylori-related diseases.
Plants that grow more slowly stay fresh longer. In their study now published in PLoS Biology, scientists at the Max Planck Institute for Developmental Biology in Tübingen have shown that certain small sections of genes, so-called microRNAs, coordinate growth and aging processes in plants. These microRNAs inhibit certain regulators, known as TCP transcription factors. These transcription factors in turn influence the production of jasmonic acid, a plant hormone.
Chicago, IL – Honey is very effective in killing bacteria in all its forms, especially the drug-resistant biofilms that make treating chronic rhinosinusitis difficult, according to research presented during the 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO, in Chicago, IL.
Chicago, IL – Even as more and more people in the United States are diagnosed with obstructive sleep apnea (OSA), there remains a disconnect as to who can benefit from corrective surgery. Leading experts in the field of sleep medicine will attempt to answer the question of who could benefit from surgery, during a moderated discussion at the 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO, in Chicago, IL.
New Haven, Conn. —Yale scientists report that genetic traces of extinct species of Galapagos tortoises exist in descendants now living in the wild, a finding that could spur breeding programs to restore the species, The report appears in Proceedings of the National Academy of Sciences.
Boston – Men over 70 years of age with early-stage prostate cancer have 20 percent higher mortality if they are treated first with hormone therapy before being treated with radiation seed implants (brachytherapy), compared to men who are treated with brachytherapy alone, according to the largest cohort study of its kind presented September 23, 2008, at the American Society for Therapeutic Radiology and Oncology's 50th Annual Meeting in Boston.
Boston – Long-term survivors of adult cancers are almost twice as likely to report psychological distress severe enough to cause moderate to serious problems functioning in social, work or school situations, compared to the general population, according to a large, national study presented September 24, 2008, at the American Society for Therapeutic Radiology and Oncology's 50th Annual Meeting in Boston.
Boston – Doctors have created a free online computer tool, the CaP Calculator, that provides cancer specialists access to the latest prostate cancer research and helps them better individiualize each patient's treatment options, according to a study presented in a scientific session on September, 23, 2008, at the American Society for Therapeutic Radiology and Oncology's 50th Annual Meeting in Boston.
Exposure to an excess of sexual steroids, like testosterone, during fetal development may be a potential risk factor for low sperm count and motility, according to a new study accepted for publication in Endocrinology, a journal of The Endocrine Society.