Body | Page 3313 | Science Codex

New therapeutic target to combat liver cancer discovered

Researchers at CIC Biogune, the Cooperative Centre for Research into Biosciences and led by Dr. Maria Luz Martinez Chantar, have found a strong relationship between high levels of Hu antigen R (HuR) protein and the malignancy of Hepatocellular Carcinoma, through a novel molecular process in the investigation of this pathology and known as neddylation. The project provides new opportunities for making advances in the quest for personalised therapeutic applications in the treatment for Hepatocarcinoma.

System to deliver organ transplant drug -- without harmful side effects

A new system for delivering a drug to organ transplant patients, which could avoid the risk of harmful side effects, is being developed by scientists at the University of Strathclyde in Glasgow.

The drug, cyclosporine (CsA), is widely used in transplant operations and helps prevent the patient's body rejecting the organ but it can cause adverse drug reactions, of which the most serious problems are kidney and liver damage, in the doses which are currently administered in the long term.

Cosmology in a Petri dish

Scientists have found that micron-size particles which are trapped at fluid interfaces exhibit a collective dynamic that is subject to seemingly unrelated governing laws. These laws show a smooth transitioning from long-ranged cosmological-style gravitational attraction down to short-range attractive and repulsive forces. The study by Johannes Bleibel from the Max Planck Institute for Intelligent Systems in Stuttgart, Germany, and his colleagues has just been published in the journal EPJ E¹ .

Prevalence of oral HPV infection higher among men than women

CHICAGO – The overall prevalence of oral human papillomavirus (HPV) infection is approximately 7 percent among men and women ages 14 to 69 years in the United States, while the prevalence among men is higher than among women, according to a study appearing in JAMA. The study is being released early online to coincide with its presentation at the Multidisciplinary Head and Neck Cancer Symposium.

Newer radiation technology improves head and neck cancer patients' long-term quality of life

Patients treated with IMRT for head and neck cancer report an increasingly better quality of life post-treatment when compared to patients receiving other forms of radiation therapy, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM.

Radiation plus chemotherapy provides long-term positive results for head and neck cancer patients

A select subgroup of advanced head and neck cancer patients treated with radiation therapy plus the chemotherapy drug cisplatin had more positive outcomes than patients treated with radiation therapy alone and continued to show positive results 10 years post-treatment, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM.

Oral HPV infection, HPV-related cancers more common in men

Oral HPV infection is more common among men than women, explaining why men are more prone than women to develop an HPV related head and neck cancer, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM.

Danish health care fast track program reduces cancer patients' treatment, diagnosis wait time

In Denmark, implementing a national fast track system for cancer patients reduced the waiting time between a patient's initial meeting with a health care provider and their first treatment by four weeks when comparing 2010 to 2002, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM.

Erlotinib dose-adjusted for smoking status effective as first treatment for head and neck cancer

Head and neck cancers respond well to the anti-cancer drug erlotinib when it is administered before surgery and a stronger dose is given to patients who smoke, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM.

Erlotinib is an oral anti-cancer drug that can slow a tumor's growth and spread by inhibiting specific growth receptors on the surface of the cancer cells. Early detection of a patient's response to EGFR inhibitors, such as erlotinib, is critical to personalizing head and neck cancer treatments.

Routine follow-up scans can detect head and neck cancer recurrences earlier

Routine use of positron emission tomography/computed tomography (PET/CT) scans in head and neck cancer patient follow-up can detect local recurrences before they become clinically apparent and may improve the outcome of subsequent salvage therapy, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM.

Ontario's first cardiac stem cell transplant performed last week at the Peter Munk Cardiac Centre

Heart failure is a leading cause of death in Canada. As part of the ongoing IMPACT-CABG clinical trial to treat advanced heart failure, physicians at the Peter Munk Cardiac Centre performed the first cardiac stem cell transplant in Ontario last week using stem cells derived from the patient's own bone marrow, isolated completely within the operating room, and implanted into the heart at the time of coronary bypass surgery. Researchers hope that stem cell therapy may be developed into a novel treatment for the 50,000 Canadians diagnosed each year with advanced heart failure.

Tiny crooners: Male house mice sing songs to impress the girls

It has been known for some time that house mice (Mus musculus) produce ultrasonic vocalizations (USVs) during courtship but it has generally been assumed that these are no more than squeaks. However, recent spectrographic analyses have revealed that USVs are complex and show features of song. Although the vocalizations are inaudible to human ears, when playbacks of recorded songs are slowed down their similarity to bird song becomes striking.

Extreme droughts could increase by 15 percent in Spain by the middle of the century

A team at the Polytechnic University of Cartagena has designed a new method for calculating drought trends. Initial results suggest that by the year 2050 there could be a 15% increase compared to the droughts seen in 1990 in the Segura river basin.

Birth after cancer treatment with removal and storage of ovary

For the first time in Germany, a woman has given birth to a child after removal and preservation of tissue from one of her ovaries. This course of action was necessary to avoid infertility owing to chemo- and radiotherapy. Andreas Müller and his colleagues report the case in the current issue of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2012; 109[1-2]: 8-13).

How the Big Three forgot Accounting 101

EAST LANSING, Mich. — The Big Three were so driven by short-term profits that they forgot – or ignored – basic accounting practices that could have helped guard against production decisions with long-term damage, according to an award-winning study by Michigan State University and Maastricht University in the Netherlands.

Essentially, the domestic automakers built far more vehicles than they needed while failing to appropriately account for the costs of excess capacity or the damage the overproduction would have on their reputations.