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Boston, MA — Using whole-genome sequencing, a team led by researchers from Harvard School of Public Health (HSPH) and the Broad Institute has traced the path of the E. coli outbreak that sickened thousands and killed over 50 people in Germany in summer 2011 and also caused a smaller outbreak in France. It is one of the first uses of genome sequencing to study the dynamics of a food-borne outbreak and provides further evidence that genomic tools can be used to investigate future outbreaks and provide greater insight into the emergence and spread of infectious diseases.

MADISON – When William Murphy works with some of the most powerful tools in biology, he thinks about making tools that can fit together. These constructions sound a bit like socket wrenches, which can be assembled to turn a half-inch nut in tight quarters, or to loosen a rusted-tight one-inch bolt using a very persuasive lever.

Reston, Va. -- In two new studies featured in the February issue of the Journal of Nuclear Medicine, researchers are revealing how molecular imaging can be used to solve mysteries about difficult cases of breast cancer. One article focuses on an imaging agent that targets estrogen receptors in estrogen receptor–positive breast cancer patients with formerly inconclusive assessments, and the second highlights a different imaging agent's ability to help predict the prognosis for patients undergoing chemotherapy for a very aggressive type of breast cancer.

Grand Rapids, Mich. – A recent discovery by Van Andel Research Institute (VARI) scientists enables the prediction of patient sensitivity to proposed drug therapies for glioblastoma – the most common and most aggressive malignant brain tumor in humans.

The study, published in January in the Proceedings of the National Academy of Science, investigated glioblastoma models characterized by cell signaling activation and gene amplification for their susceptibility to inhibitors of both the human MET oncogene and the epidermal growth factor receptor (EFGR).

GAINESVILLE, Fla. – Satellite tracking of threatened loggerhead sea turtles has revealed two previously unknown feeding 'hotspots' in the Gulf of Mexico that are providing important habitat for at least three separate populations of the turtles, according to a study published recently in the journal Biological Conservation.

The two sites, located in the open waters off the coast of Southwest Florida and the northern tip of the Yucatan Peninsula, were found by a team of scientists when they compiled and analyzed loggerhead tracking data.

(Santa Barbara, Calif.) –– Infectious disease has joined poaching and habitat loss as a major threat to the survival of African great apes as they have become restricted to ever-smaller populations. Despite the work of dedicated conservationists, efforts to save our closest living relatives from ecological extinction are largely failing, and new scientific approaches are necessary to analyze major threats and find innovative solutions.

ORLANDO, Fla., February 6, 2012 – It's well known that exercising reduces body weight because it draws on fat stores that muscle can burn as fuel. But a new study at Sanford-Burnham Medical Research Institute (Sanford-Burnham) suggests that the heart also plays a role in breaking down fat. In their study, published February 6 in the Journal of Clinical Investigation, Sheila Collins, Ph.D. and colleagues detail how hormones released by the heart stimulate fat cell metabolism.