Rice University researchers have found a way to divide and modify enzymes to create what amounts to a genetic logic gate.
Biochemist Matthew Bennett and graduate student David Shis created a library of AND gates by mutating a protein from a bacterial virus. The well-understood protein known as T7 RNA polymerase (RNAP) is a strong driver of transcription in cells.
Biologists since Aristotle have puzzled over the reasons for mass strandings of whales and dolphins, in which groups of up to several hundred individuals drive themselves up onto a beach, apparently intentionally. Recent genetic research has shed some light on whether family relationships play a role in these enigmatic and often fatal beachings of otherwise healthy whales.
NEWPORT, Ore. – Pilot whales that have died in mass strandings in New Zealand and Australia included many unrelated individuals at each event, a new study concludes, challenging a popular assumption that whales follow each other onto the beach and to almost certain death because of familial ties.
Using genetic samples from individuals in large strandings, scientists have determined that both related and unrelated individuals were scattered along the beaches – and that the bodies of mothers and young calves were often separated by large distances.
PHILADELPHIA - Brown fat is a hot topic, pardon the pun. Brown fats cells, as opposed to white fat cells, make heat for the body, and are thought to have evolved to help mammals cope with the cold. But, their role in generating warmth might also be applied to coping with obesity and diabetes.
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget's Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS).
Single mutations in one gene rarely cause such different diseases. This study shows that these mutations disrupt energy production in cells shedding new light on the role of VCP in these multiple disorders.
Sexting: Involves sending sexually explicit messages and/or photographs, primarily between mobile phones using the SMS system was first reported in 2005. It is an obvious portmanteau of "sex" and "texting"; the word was added to the Merriam-Webster's Collegiate Dictionary in August 2012. 4% of mobile phone-owning teens claim to have sent sexually suggestive, nude or nearly nude images or videos of themselves to someone else via a mobile device while 15% claim to have received such material from someone they know.
New Rochelle, NY, March 14, 2013—Severe chronic pain associated with conditions such as bladder pain syndrome/interstitial cystitis often require the use of opioid medication, with the risk of dependency and serious adverse reactions. An alternative treatment strategy increases the levels of a naturally occurring painkiller in and around the nerves that deliver pain signals to the bladder. This new therapeutic approach is described in an article in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
Completion rates for the human papillomavirus (HPV) vaccine series across both genders continue to remain alarmingly low nearly seven years after its introduction, suggesting that better patient education and increased public vaccine financing programs are needed, according to new research from the University of Texas Medical Branch (UTMB).
The researchers report "startling" trends in a series of three separate studies published in Cancer, Human Vaccines & Immunotherapeutics and Vaccine.
How much of the United States' newfound bounty of natural gas should stay at home, keeping prices low for domestic customers? How much should be earmarked for export in the form of liquefied natural gas (LNG), at the risk of making natural gas pricier? Those questions are the topic of the cover story in the current edition of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, the world's largest scientific society.
(WASHINGTON)-Transplants of blood-forming stem cells from umbilical cord blood may be an effective alternative to transplants of matched donor bone marrow stem cells to treat children with a rare, debilitating disease known as Hurler's syndrome (HS), according to results of a study published online today in Blood, the Journal of the American Society of Hematology (ASH).
TORONTO, ON — Researchers from the University of Toronto and SickKids Research Institute announced today that they have successfully mapped the genes in the fungus that causes Dutch Elm Disease.
The researchers believe this is the first time the 30 million DNA letters for the fungus Ophiostoma ulmi have been mapped. The findings, published in this week's online journal BMC Genomics, could help scientists figure out how to prevent the fungus from destroying elm trees in the future.
A virus that most people have probably never heard of, yet most of us carry, is the number 1 infectious cause of congenital birth defects. One in 750 children are born with, or develop, permanent disabilities such as hearing loss or brain damage as a result of CMV (cytomegalovirus) infection in the womb. Major research efforts are underway to combat this invidious disease.
Researchers from Cardiff University and the La Jolla Institute, California, have discovered a previously unknown cellular mechanism that could prove critical in creating a CMV vaccine.
Valdivia, Chile, and Washington, D.C.—Cancer cells break down sugars and produce the metabolic acid lactate at a much higher rate than normal cells. This phenomenon provides a telltale sign that cancer is present, via diagnostics such as PET scans, and possibly offers an avenue for novel cancer therapies. Now a team of Chilean researchers at The Centro de Estudios Científicos (CECs), with the collaboration of Carnegie's Wolf Frommer, has devised a molecular sensor that can detect levels of lactate in individual cells in real time.
Terahertz (THz) radiation, a slice of the electromagnetic spectrum that occupies the middle ground between microwaves and infrared light, is rapidly finding important uses in medical diagnostics, security, and scientific research. As scientists and engineers find evermore practical uses for this form of radiation, questions persist about its potential human health risks.
The beetle family Cerambycidae, also known as long-horned beetles or longicorns, is characterized by emblematic extremely long antennae, which are usually longer than the total body length of the animal. The family is rather rich in diversity with more than 20 000 species known, distributed worldwide. Some representatives of these bizarre-shaped beetles, are also known as serious pests with their wood-feeding larvae causing extensive damage to living trees or untreated lumber.