- Researchers found a strong, graded association between worse kidney function and the presence of hypertension that is resistant to medications.
- More than 50% of individuals with moderate CKD had resistant hypertension.
- Among people with CKD, blacks and those with a larger waist circumference, diabetes, and a history of heart attacks or strokes were more likely to have resistant hypertension.
- 60 million people globally have chronic kidney disease.
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Antibiotic-resistant bacteria have been emerging at an alarming rate. In some of the scariest of these pathogens, the mechanism responsible for the bacteria's ability to defeat antibiotics is a complex protein molecule embedded in the bacterial cell wall -- the enzyme β-lactamase.
Breaking a sweat while working out regularly may reduce your risk of stroke, according to new research in the American Heart Association journal Stroke.
In a study of more than 27,000 Americans, 45 years and older who were followed for an average of 5.7 years, researchers found:
Boys are more likely to receive the quadrivalent human papillomavirus vaccine (HPV4) if their mothers receive flu shots or Pap screenings, according to a Kaiser Permanente study published in the American Journal of Public Health.
The widespread rejection of estrogen therapy after the 2002 Women's Health Initiative (WHI) study has most likely led to almost 50,000 unnecessary deaths over the last 10 years among women aged 50 to 69 who have had a hysterectomy, Yale School of Medicine researchers reveal in a study published in the July 18 issue of the American Journal of Public Health.
LA JOLLA, CA---- Stem cells are key to the promise of regenerative medicine: the repair or replacement of injured tissues with custom grown substitutes. Essential to this process are induced pluripotent stem cells (iPSCs), which can be created from a patient's own tissues, thus eliminating the risk of immune rejection. However, Shinya Yamanaka's formula for iPSCs, for which he was awarded last year's Nobel Prize, uses a strict recipe that allows for limited variations in human cells, restricting their full potential for clinical application.
The risk of catching some nasty germ in the Hudson River just started looking nastier. Disease-causing microbes have long been found swimming there, but now researchers have documented antibiotic-resistant strains in specific spots, from the Tappan Zee Bridge to lower Manhattan. The microbes identified are resistant to ampicillin and tetracycline, drugs commonly used to treat ear infections, pneumonia, salmonella and other ailments. The study is published in the current issue of the Journal of Water and Health.
PROVIDENCE, R.I. – Rhode Island Hospital researchers have found that the absence of the Shp-2 enzyme near specialized cartilage cells can lead to the development of multiple benign cartilage tumors in mice, a model that recapitulates the rare human tumor syndrome metachondromatosis. Shp2 is an enzyme in the cell that regulates the activity of other proteins and signaling pathways. Mice lacking Shp2 formed two types of tumors: enchondromas and osteochondromas, and also developed deformed joints. The study is published online in advance of print in the journal Nature.
In the study, the researchers captured movies of blood stem cells taken from transgenic mice. The cells expressed a green fluorescent protein that serves as an indicator of PU.1 levels in the cell: the brighter the cells appeared in the movies, the more PU.1 was present. By measuring PU.1 levels over time using this indicator, the scientists were able to monitor changes in the rate of PU.1's synthesis.
Designing an effective HIV/AIDS vaccine is something of a paradox: a good vaccine would be safe and look enough like HIV to kick-start the immune system into neutralizing the virus – but the problem is that this is exactly what the human immune system has trouble doing even when it's exposed to the real thing.
Boston, Mass., July 18, 2013 - Researchers at Boston Children's Hospital have identified a genetic cause of severe obesity that, though rare, raises new questions about weight gain and energy use in the general obese population. The research, published in the journal Science on July 19, involved genetic surveys of several groups of obese humans and experiments in mice.
You are not just yourself. You are also the thousands of microbes that you carry. In fact, they represent an invisible majority that may be more you than you realize.
These microscopic fellow travelers are collectively called the microbiome. Realization that every species of plant and animal is accompanied by a distinctive microbiome is old news. But evidence of the impact that these microbes have on their hosts continues to grow rapidly in areas ranging from brain development to digestion to defense against infection to producing bodily odors.
CAMBRIDGE, Mass. (July 18, 2013) – Protein production or translation is tightly coupled to a highly conserved stress response that cancer cells rely on for survival and proliferation, according to Whitehead Institute researchers. In mouse models of cancer, targeted therapeutic inhibition of translation disrupts this survival response, dramatically slowing tumor growth and potentially rendering drug-resistant tumors vulnerable to other therapies.
In an international collaborative project, scientists have recorded the times, places and concentrations of oceanic plankton occurrences worldwide. Their data has been collected in a global atlas that covers organisms from bacteria to krill.
Boston, Mass., July 18, 2012 – Ending a 30-year search by scientists, researchers at Boston Children's Hospital have identified two proteins in the inner ear that are critical for hearing, which, when damaged by genetic mutations, cause a form of delayed, progressive hearing loss. Findings were published online July 18 by the journal Neuron.