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PHILADELPHIA - Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell therapy, and new research from the Abramson Cancer Center of the University of Pennsylvania is shedding light on why. In a new study, researchers describe how a death receptor pathway in the cancer cell itself plays a central role in determining its response to CAR T cells. It's the first study to show that natural cancer features can influence response to CAR T cells, and that cancer cells can drive the development of CAR T cell dysfunction.
Developing a therapy to combat cancer remains one of the most difficult challenges in medical research. Cancer owes its notorious identity to the fact that the cancer cells use the host's own immune system to grow and spread, ultimately becoming deadly. Immune cells like macrophages, which ordinarily fight to protect normal cells, are hijacked by malignant cancer cells, and populate the environment around the tumors, becoming tumor-associated macrophages (TAMs).
Mason, OH - Thursday, January 30, 2020 - Undiagnosed chest pain sends 8-10 million Americans to Emergency Departments annually, making it the second most common complaint. Emergency physicians must rapidly identify patients whose chest pain is cardiac-related. A new pilot study has found that a resting 90-second magnetocardiography (MCG) scan shows promise in evaluating emergency department observation unit (EDOU) chest pain patients for Acute Coronary Artery Syndrome.
This is the finding of a team of international scientists, led by Imperial College London, and including researchers from the University of California and University of Florida.
The Imperial team, based at J-IDEA, the Abdul Latif Jameel Institute for Disease and Emergency Analytics, created the first ever global map of dengue transmission intensity - which is a measure of how easily dengue is transmitted from person to person.
January 29, 2020 - Used for facial rejuvenation, dermal fillers do more than just fill in wrinkles. According to a new study in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS), they also restore a more youthful
A new analysis, published in The Lancet, includes 99 patients with laboratory-confirmed 2019 novel coronavirus (2019-nCoV) who were transferred to Jinyintan Hospital, an adult infectious disease hospital admitting the first 2019-nCoV cases from hospitals across Wuhan, between January 1 and January 20, 2020. The study includes the first 41 cases from Wuhan reported in The Lancet last week [1].
During visits to fields in Assam, Rajasthan and Uttar Pradesh, India, plant biologists Muthappa Senthil-Kumar and Urooj Fatima found mustard plants infested with Alternaria blight disease. They also noticed that an adjacent field of chickpeas were completely uninfected.
LOS ANGELES – When someone has an acute stroke, early access to specialized care is crucial. Whenever possible, experts recommend people receive medical help at a hospital with advanced stroke capability like a comprehensive stroke center (CSC).
Dr Pascal Duijf from QUT's School of Biomedical Sciences and IHBI (Institute of Health and Biomedical Innovation) said the study, published in Nature Communications today, analysed chromosome arm abnormalities in more than 23,000 human tumours and 1000 cancer cell lines.
"Our analyses provided hitherto unknown insights into the evolution of tumours and open up three exciting new areas of study, including new potential personalised treatments for 17 cancer types," Dr Duijf said.
Chronic lymphocytic leukemia (CLL) is the most common form of blood cancer (leukemia) in the Western world, affecting approximately 1.2% of all cancer patients. This type of cancer starts with the lymphocytes (a type of white blood cells) that are produced in the bone marrow. CLL is characterized by the proliferation of abnormal lymphocytes (B cells) that fail to mature and grow out of control. These abnormal cells accumulate in the bone marrow and lymph nodes, taking the place of other healthy cell types and impeding their normal development.
Claudio Franceschi, a world-renowned scientist, professor at the University of Bologna (Italy) and head of the Research Laboratory for Systems Medicine of Healthy Aging at Lobachevsky University, together with other members of an international research team, has described the mechanisms underlying chronic inflammation and identified several risk factors leading to disease.
The adoption of children is a fundamental method of building families. However, adoptees may face subsequent adaptive challenges associated with family stress at the time of birth and during the adoption process.
U.S. combat soldiers who suffered a moderate or severe traumatic brain injury (TBI) are more likely than soldiers with other serious injuries to experience a range of mental health disorders, according to a new retrospective study by University of Massachusetts Amherst health services researchers.
American and British teams led by Drs Kohn (University of California, Los Angeles), Malech (NIH), Williams (Boston Children's) and Trasher (Great Ormond Street Institute of Child Health) published yesterday in Nature Medicine the conclusive results of a gene therapy trial conducted in the United States and Great Britain in 9 patients with X-linked Chronic Septic Granulomatosis (X-CGD), a rare and severe immune dysfunction. Six of them are free of treatment for complications generated by the disease.
Mixing drinking water with chlorine, the United States' most common method of disinfecting drinking water, creates previously unidentified toxic byproducts, says Carsten Prasse from Johns Hopkins University and his collaborators from the University of California, Berkeley and Switzerland.
The researchers' findings were published this past week in the journal Environmental Science & Technology.