Body

SINGAPORE, 15 January 2020 - A key mechanism underlying neuronal dysfunction in Angelman syndrome (AS), a syndromic form of autism spectrum disorder, has - for the first time - been revealed through innovative research led by Duke-NUS Medical School and the National Neuroscience Institute (NNI) under the National Neuroscience Research Institute Singapore (NNRIS) - a joint venture combining neuroscience research expertise from both organisations.

A new computer algorithm can predict in the early stages of pregnancy, or even before pregnancy has occurred, which women are at a high risk of gestational diabetes - according to a study by researchers at the Weizmann Institute of Science reported today in Nature Medicine. The study analyzed data on nearly 600,000 pregnancies available from Israel's largest health organization, Clalit Health Services. Based on these predictions, it may be possible to prevent gestational diabetes using nutritional and lifestyle changes.

Research team leader Marina Gomzikova, employee of the Gene and Cell Technologies Lab, started working on extracellular microvesicles (ECMVs) in 2013, when she was enrolled in her PhD course. Since then, very promising properties were found in ECMVs derived from human mesenchymal stem cells (MSCs).

Amsterdam, NL, January 15, 2020 -In this collection of articles in the Journal of Pediatric Rehabilitation Medicine (JPRM) experts highlight the emerging trends in spina bifida care in response to challenges faced by spina bifida patients and their physicians due to demographic shifts in age and ethnicity and other societa

LA CROSSE, Wis. -- Fewer physicians are pursuing careers in obstetrics, in part because of the intense, round-the-clock demands of the job and a high burnout rate. An unusually large number of practicing obstetricians are expected to retire within the next decade, which will add to an already acute physician shortage.

NEW YORK, NY (Jan. 15, 2020)--The source of essential tremor--a movement disorder that causes involuntary trembling of the hands, arms, and head--has been enigmatic, impeding the development of effective treatments for a condition that affects 4% of people over 40.

Now a new study from Columbia University Irving Medical Center and NewYork-Presbyterian suggests the tremors are caused by overactive brain waves at the base of the brain, raising the possibility of treating the disorder with neuromodulation to calm the oscillations.

DALLAS - Jan. 15, 2020 - A UT Southwestern study is challenging concerns that a federal health policy enacted in 2012 to reduce hospital readmissions leaves patients more vulnerable.

The researchers, whose findings published today in BMJ, poured over nine years' worth of Medicare claims data to report on outcomes of patients who received care in observation units and emergency departments in the 30-day period following hospitalization.

One in five young people have fatty liver disease (steatosis), with one in 40 having already developed liver scarring (fibrosis), research published today [15 January] has found. The study, published in The Lancet Gastroenterology & Hepatology, is the first to attempt to determine the prevalence of fatty liver disease and fibrosis in young healthy adults in the UK.

New Rochelle, NY, January 15, 2020--As more states legalize medicinal and recreational cannabis use and increasingly decriminalize cannabis, the risk to the growth and development of breastfeeding infants whose mothers use cannabis becomes a growing public health concern. The critical role that certified lactation consultants (CLCs) could play in postpartum management of cannabis use and a Call to Action to expand the role of CLCs is published in Breastfeeding Medicine, the official journal of the Academy of Breastfeeding Medicine published by Mary Ann Liebert, Inc., publishers.

Soft tissue sarcomas are a heterogenous group of aggressive, chemotherapy-resistant cancers that affect the soft tissues of the body (fat, muscles, fibrous tissue, blood and lymphatic vessels, nerves, etc.). In the current clinical trials, only 15% of patients respond to immunotherapy, which raises the question of the needless exposure of the other patients to the toxicity of these treatments. Identifying markers that predict their response to immunotherapy is therefore crucial.

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. In a new paper, published online January 14, 2020 in the journal Aging Cell, researchers at University of California San Diego School of Medicine say the gene appears to play a key role in age-associated functional and anatomical aging in vivo in mouse retinas, a finding that has direct relevance to age-related eye diseases.

A Brazilian study published in the journal Drug and Alcohol Dependence shows that cannabis smoked recreationally does not work as a harm reduction strategy for crack and cocaine addicts undergoing rehabilitation. Instead of reducing their craving for cocaine, whether nasally insufflated in powder form or smoked in the form of crack crystals, cannabis use made the patients' clinical condition worse.

New Haven, Conn. -- The Obamacare program intended to reduce the risk of patients being readmitted after hospitalizations for heart attacks, heart failure, and pneumonia has not caused an increase in mortality risk for patients in emergency departments or observational units, according to a new report.

Doctors from Yale and the University of Texas (UT) Southwestern Medical Center conducted the study, which appears Jan. 15 in The BMJ (British Medical Journal).

The world's most common vision problem myopia or short/near sightedness, which causes damage to the eye and even blindness, just got easier to assess.

Progressive research at Flinders University in Australia has identified a new method to measure how it affects the eye, a new article in PLOS ONE reveals.