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Researchers from St. Jude Children's Research Hospital and the Chinese Children's Cancer Group led the first randomized, Phase III clinical trial comparing targeted therapies for acute lymphoblastic leukemia (ALL) driven by the Philadelphia chromosome. Results showed that the drug dasatinib provides more benefit than the standard of care, which led to changes in the way this leukemia is treated. The findings were reported today in JAMA Oncology.
Zika virus infection can stunt neonatal brain development, a condition known as microcephaly, in which babies are born with abnormally small heads. To determine how best to prevent and treat the viral infection, scientists first need to understand how the pathogen gets inside brain cells.
Employing different approaches to answer different questions, two research teams at University of California San Diego School of Medicine independently identified the same molecule -- αvβ5 integrin --as Zika virus' key to entering brain stem cells.
A study of families in Singapore with terminally ill children found that parents tend to defer discussing their psychological pain with their spouses to protect them from emotional distress.
The study, conducted by psychologists at Nanyang Technological University, Singapore (NTU Singapore) through interviews, revealed the parents' preference to support each other in pragmatic and solution-oriented ways such as discussing treatment options, arranging care plans and sharing caregiving responsibilities.
The use of antipsychotics is associated with increased risks of head and brain injuries among persons with Alzheimer's disease, according to a recent study from the University of Eastern Finland. The risk increase was highest at the initiation of antipsychotic use. The results were published in the Journal of the American Geriatrics Society (JAGS).
A new study, published in PeerJ, shows how University of Liverpool researchers have used a newly developed eye movement test to improve the understanding of how parts of the brain work.
New research has discovered that Down's syndrome, Fragile X syndrome and Williams syndrome are all linked to sleep disruption in very young children, and that sleep plays a crucial role in the development of these children's language skills.
Led by Dr Dean D'Souza of Anglia Ruskin University (ARU) and published in the journal Research in Developmental Disabilities, it is the first cross-syndrome study to examine sleep, and the relationship between sleep and language, in very young children with these neurodevelopmental disorders.
BUFFALO, N.Y. -- Research by University at Buffalo biologists is providing new insights into alpha-synuclein, a small acidic protein associated with Parkinson's disease.
Alpha-synuclein is known to form abnormal clumps in the brains of patients with Parkinson's, but scientists are still trying to understand how and why this happens.
The Akay Lab biomedical research team at the University of Houston is reporting an improvement on a microfluidic brain cancer chip previously developed in their lab. The new chip allows multiple-simultaneous drug administration, and a massive parallel testing of drug response for patients with glioblastoma (GBM), the most common malignant brain tumor, accounting for 50% of all cases. GBM patients have a ?ve-year survival rate of only 5.6%.
Today, OncoTartis, Inc. and Children's Cancer Institute jointly announced the publication of two research manuscripts in a leading onco-hematological journal Leukemia, both devoted to the OncoTartis' clinical drug candidate OT-82.
Epigenetic changes occur in the DNA of breast cancer cells that have developed a resistance to hormone therapy, an effective treatment for ER+ breast cancer, which accounts for 70% of all diagnoses.
Reversing these changes, researchers say, has significant potential to help reduce breast cancer relapse.
LOS ANGELES (EMBARGOED UNTIL Jan. 15, 2020, at 11AM EST) -- New research from the Smidt Heart Institute at Cedars-Sinai showed for the first time that women's blood vessels - including both large and small arteries - age at a faster rate than men's. The findings, published Wednesday in the journal JAMA Cardiology, could help to explain why women tend to develop different types of cardiovascular disease and with different timing than men.
A pilot study of 25 donor-recipient pairs reveals that healthy young donors of stem cells harbor previously undetected and potentially disease-causing mutations in their blood stem cells, which were transferred to unrelated recipients of the transplants. Although more comprehensive studies are needed, the findings imply that these mutations - which have been linked to post-transplant complications - are more prevalent in young donors than previously thought. Stem cell transplants can treat or even cure blood-related diseases such as enzyme deficiencies and some blood cancers.
New Haven, Conn. -- In the largest examination to date of the health consequences of ageism, or age-based bias, researchers at the Yale School of Public Health have found evidence that it harms the health of older people in 45 countries and across 5 continents. The study included over 7 million participants.
Boston, MA -- A new analysis provides evidence that may change the current thinking around categorizing patients with heart failure prior to implanting a left-ventricular assist device (LVAD). Currently, clinicians and regulatory agencies divide patients who receive LVADs into two distinct categories: those receiving a device as a bridge to transplant (BTT) and those for whom the device is considered a destination therapy (DT). For BTT patients, the device is intended to extend survival until they can receive a heart transplant. For DT patients, the device is intended for long-term use.
NOx gases is the generic term to refer to the group of gases made up of nitric oxide and nitrogen dioxide, gases that result from burning fossil fuel, and also from forest fires, volcanic eruptions and natural processes of transforming nitrogen in soil. Even so, the greatest concentration is usually found in urban areas, where they are toxic for our health and contribute to global warming and acid rain.