Body

From uncharted region of human genome, clues emerge about origins of coronary artery disease

Scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory have learned how an interval of DNA in an unexplored region of the human genome increases the risk for coronary artery disease, the leading cause of death worldwide.

Their research paints a fuller picture of a genetic risk for the disease that was discovered only three years ago and which lurks in one out of two people.

New insights into helping marine species cope with climate change

Move, adapt or die. Those are the options marine plants and animals have in the face of climate change, said Stanford biologist Steve Palumbi, who has been exploring how to help them go with the first two options, rather than the third. He's come up with some surprising answers.

Palumbi will be discussing the results of his research in two talks at the annual meeting of the American Association for the Advancement of Science in San Diego.

Black women at increased risk for weakened heart muscle at childbirth

Black women are at significantly increased risk for developing a potentially deadly weakening of the heart muscle around the time of childbirth, researchers report.

A study examining the incidence of peripartum cardiomyopathy in women who gave birth at a Medical College of Georgia's teaching hospital between July 2003 and July 2008, showed that while 55 percent of the women were white, 93 percent of those who developed cardiomyopathy were black, said Dr. Mindy B. Gentry, an MCG cardiologist.

Unpacking condensins' function in embryonic stem cells

Regulatory proteins common to all eukaryotic cells can have additional, unique functions in embryonic stem (ES) cells, according to a study in the February 22 issue of the Journal of Cell Biology (www.jcb.org). If cancer progenitor cells—which function similarly to stem cells—are shown to rely on these regulatory proteins in the same way, it may be possible to target them therapeutically without harming healthy neighboring cells.

Diffusion of a soluble protein through a sensory cilium

A team of researchers led by Peter Calvert (SUNY Upstate Medical University) has, for the first time, measured the diffusion coefficient of a protein in a primary cilium and in other major compartments of a highly polarized cell. The study appears in the March issue of the Journal of General Physiology (www.jgp.org).

Diapers' contents could change way of finding intestinal disease

Evidence-based care and outcomes improve at Get With The Guidelines-Stroke hospitals

Acute stroke care and clinical outcomes have improved significantly at hospitals participating in the American Heart Association/American Stroke Association's Get With The Guidelines–Stroke program, according to a large study in Circulation: Cardiovascular Quality and Outcomes, a journal of the American Heart Association.

Animals linked to human Chlamydia pneumoniae

Animals have been found to have infected humans sometime in the past with the common respiratory disease Chlamydia pneumoniae, according to Queensland University of Technology infectious disease expert Professor Peter Timms.

Unlike the sexually-transmitted form of Chlamydia, Chlamydia pneumoniae is a major bacterial germ that causes widespread respiratory disease in humans.

Survey finds significant racial differences in lung cancer beliefs

A new survey finds that while both whites and African Americans know and think little about lung cancer, African Americans are more likely to hold beliefs and perceptions about the disease that could interfere with prevention and treatment. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the report indicates that public health messages regarding lung cancer should be targeted to all communities.

African-Americans' attitudes about lung cancer may hinder prevention

BOSTON - A new survey has found that African-Americans are more likely than whites to hold mistaken and fatalistic beliefs about lung cancer, as well as being more reluctant to consult a doctor about possible symptoms of the disease, according to researchers from Dana-Farber Cancer Institute and their collaborators.

Where will the next food crisis strike and how to face it?

The European Commission Joint Research Centre (JRC), the Food and Agriculture Organization of the United Nations (FAO) and the American Famine Early Warning Systems Network (FEWS NET) are working to innovate and reinforce their food security monitoring systems and to develop more efficient early warning tools. These efforts come as a response to the 2007-2008 global food crisis that increased significantly the number of countries under threat of famine.

Genome analysis of marine microbe reveals a metabolic minimalist

SANTA CRUZ, CA--Flightless birds, blind cave shrimp, and other oddities suggest a "use it or lose it" tendency in evolution. In the microbial world, an unusual marine microorganism appears to have ditched several major metabolic pathways, leaving it with a remarkably reduced set of genes.

When the heart gets out of step

Atrial fibrillation is a cardiac arrhythmia – a chronic irregularity of heartbeat – which affects an estimated 1 million people in Germany. Although the condition is not acutely life-threatening, it does increase the risk of developing more serious illnesses, such as cardiac insufficiency, stroke and dementia. In the third of a series of genomewide asssociation studies, an international team of researchers, led by LMU physician PD Dr. Stefan Kääb, now reports the identification of a new gene locus that has a significant influence on risk for atrial fibrillation.

Common gene variant may increase risk for a type of cardiac arrhythmia

An international research team has identified a common gene variant associated with a form of the irregular heartbeat called atrial fibrillation. In their report in the journal Nature Genetics, being published online, the investigators describe finding that variations affecting a protein that may help control the heart's electrical activity appear to increase the risk of what is called lone atrial fibrillation (AF), a type seen in younger individuals with no other form of heart disease.

Enzyme deficiency protects hepatitis C patients from treatment-related anemia

DURHAM, N.C. – Many people who undergo treatment for hepatitis C develop hemolytic anemia, a disorder that destroys red blood cells. In some cases, it is so severe they have to reduce their medication or stop therapy altogether. But now, scientists in Duke University's Institute for Genome Sciences & Policy (IGSP) have discovered two genetic alterations linked to a benign enzyme condition that keep some patients anemia-free.