Body

Pitt-led international study identifies human enzyme that breaks down potentially toxic nanomaterials, opens door to novel drug

PITTSBURGH—An international study based at the University of Pittsburgh provides the first identification of a human enzyme that can biodegrade carbon nanotubes—the superstrong materials found in products from electronics to plastics—and in laboratory tests offset the potentially damaging health effects of being exposed to the tiny components, according to findings published online in Nature Nanotechnology.

Hawaiian submarine canyons are hotspots of biodiversity and biomass for seafloor animal communities

Underwater canyons have long been considered important habitats for marine life, but until recently, only canyons on continental margins had been intensively studied.

Experimental drug chokes off energy supply, kills cancer cells

COLUMBUS, Ohio – Cancer cells grow so fast that they can outstrip their blood supply, leaving them short of oxygen. The cells then produce energy in a way that needs less oxygen but more sugar.

Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have designed an experimental drug that chokes off that sugar supply, causing the cells to self destruct.

Cosmopolitan eels

Joshua Reece became interested in moray eels in 2005 when he was applying to the PhD program at the University of Hawai'i. Instead of taking him on a campus tour, his host, Brian Bowen, PhD, a biologist at the university, took him on a dive. Along the southwest coast of Oahu, Reece looked under a rock ledge and was startled to see five different species of moray eels looking back. When he later captured the eels, he found the same fish species in all of their bellies.

Household detergents, shampoos may form harmful substance in waste water

Scientists are reporting evidence that certain ingredients in shampoo, detergents and other household cleaning agents may be a source of precursor materials for formation of a suspected cancer-causing contaminant in water supplies that receive water from sewage treatment plants. The study sheds new light on possible environmental sources of this poorly understood water contaminant, called NDMA, which is of ongoing concern to health officials. Their study is in ACS' Environmental Science & Technology, a semi-monthly journal.

Nanoparticles in zinc oxide sunscreens could be toxic if accidentally eaten

Scientists are reporting that particle size affects the toxicity of zinc oxide, a material widely used in sunscreens. Particles smaller than 100 nanometers are slightly more toxic to colon cells than conventional zinc oxide. Solid zinc oxide was more toxic than equivalent amounts of soluble zinc, and direct particle to cell contact was required to cause cell death. Their study is in ACS' Chemical Research in Toxicology, a monthly journal.

ADCY5 gene provides a link between lower birth weight and type 2 diabetes

New research uncovers two genetic regions that influence birth weight. One of the regions is also associated with type 2 diabetes, which helps to explain why small babies have higher rates of diabetes in later life.

A large international team of researchers, including scientists from several UK and international centres, has discovered two gene regions that affect a baby's size at birth. The research, published in Nature Genetics, is the first robust evidence that a well-known link between lower birth weight and susceptibility to type 2 diabetes has a genetic component.

Why living things are the size they are -- and none other

If you consider yourself to be too short or too tall, things are looking up, or down, depending on your vertical disposition. New research published online in The FASEB Journal (http://www.fasebj.org) explains how we grow, how our bodies maintain correct proportions, and offers insight into what goes wrong with growth disorders and unregulated cell growth in cancer.

Does smoking compound other MS risk factors?

ST. PAUL, Minn. –A new study shows that smoking may increase the risk of multiple sclerosis (MS) in people who also have specific established risk factors for MS. The research is found in the April 7, 2010, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Most women unaware of risk for debilitating fractures

NEW YORK (April 7, 2010) – Underscoring what researchers call a serious global public health concern, results from a new study led by Columbia University Medical Center reveal that many women at an elevated level of risk for osteoporosis-associated fractures fail to perceive the implications of the risk factors.

Getting heavier, younger: U-M study shows generational shift in obesity

Ann Arbor, Mich. – It was a provocative prediction that due to the obesity epidemic Baby Boomers may outlive their children.

But a new study by the University of Michigan Health System on obesity trends shows Americans are getting heavier younger and carrying the extra weight for longer periods over their lifetime.

As a result, the study suggests the impact on chronic diseases and life expectancy may be worse than previously thought. The findings will be published April 12 in the International Journal of Obesity.

Pitt-led study identifies human enzyme that breaks down potentially toxic nanomaterials

PITTSBURGH—An international study based at the University of Pittsburgh provides the first identification of a human enzyme that can biodegrade carbon nanotubes—the superstrong materials found in products from electronics to plastics—and in laboratory tests offset the potentially damaging health effects of being exposed to the tiny components, according to findings published online in Nature Nanotechnology.

Henry Ford Hospital atudy: Hepatitis C infection doubles risk for kidney cancer

DETROIT – Physicians at Henry Ford Hospital have found that infection with the hepatitis C virus increases the risk for developing kidney cancer.

Using administrative data from more than 67,000 Henry Ford Health System patients, physicians found that over the period 1997-2008, 0.6% (17/3057) patients with hepatitis C infection developed kidney cancer whereas only 0.3% (17/64006) patients without the disease developed kidney cancer.

Genetic factor shown to regulate both heart failure and aneurysm disease

Case Western Reserve University School of Medicine researchers have identified a major indicator of two deadly diseases of the heart and blood vessels: heart failure and aortic aneurysm. The absence of the Kruppel-like Factor 15 (KLF15), when combined with stress, leads to both heart failure and aortic aneurysms. The genetic factor, KLF15, protects the heart and aorta's ability to maintain structural and functional integrity.

Researchers discover new approach for identifying smokers at highest risk for developing lung cancer

(Boston) – Researchers from Boston University School of Medicine (BUSM) in collaboration with investigators at the University of Utah, have discovered a new approach for identifying smokers at the highest risk for developing lung cancer. The findings, which appear in the April 7th issue of Science Translational Medicine, will allow the researchers to use a genomic approach to prevent lung cancer in these individuals and to personalize cancer chemoprophylaxis and therapy.