Although advances in the control and elimination of neglected infections have been steadily increasing in the past decade—specifically with heightened interest by policy makers, governments, the World Health Organization (WHO), and private philanthropies—more can and must be done, says a new editorial, "'Manifesto' for Advancing the Control and Elimination of Neglected Tropical Diseases," published May 25 in the open-access journal PLoS Neglected Tropical Diseases.