The pioneering research, using detailed computer models, could help save lives through preventative treatment of those most at risk from a form of heart rhythm disorder called sick sinus syndrome.
This occurs when the activity of the heart's pacemaker, the sinoatrial node, is impaired. Up to now, no-one has been able to work out why this happens.
But groundbreaking research by Professor Henggui Zhang at The University of Manchester shows how gene mutation and activity of the nervous system can combine to seriously disrupt the heart's normal rhythm.