Body

Washington, DC – A common virus that can cause coughing and mild diarrhea appears to have a major redemptive quality: the ability to kill cancer. Harnessing that power, researchers at Georgetown Lombardi Comprehensive Cancer Center, part of Georgetown University Medical Center, are conducting a clinical trial to see if the virus can target and kill certain tumor types.

BUFFALO, N.Y. -- Results of a new Women's Health Initiative (WHI) report show that hormone therapy is associated with an increased the risk of death from breast cancer, as well as an increased risk of developing invasive breast cancer in postmenopausal women.

Jean Wactawski-Wende, PhD, professor of social and preventive medicine at the University at Buffalo and one of the primary authors on the paper, published today in JAMA, says the breast cancers found in these women also tended to have more lymph node involvement, indicating a poorer prognosis.

The evolution of complex life is strictly dependent on mitochondria, the tiny power stations found in all complex cells, according to a new study by Dr Nick Lane, from UCL (University College London), and Dr William Martin, from the University of Dusseldorf.

"The underlying principles are universal. Energy is vital, even in the realm of evolutionary inventions," said Dr Lane, UCL Department of Genetics, Evolution and Environment. "Even aliens will need mitochondria."

HOUSTON - Long overshadowed by p53, its famous tumor-suppressing sibling, the p63 gene does the tougher, important job of stifling the spread of cancer to other organs, researchers at The University of Texas MD Anderson Cancer Center report in the Oct. 21 issue of Nature.

Not only does a specific form of p63 protein block metastasis, but it does so by activating the enzyme Dicer, which plays a pivotal role in the creation of micro RNAs, tiny bits of RNA that regulate a host of cellular processes.

The last two decades have seen tremendous progress in understanding the genetic basis of human brain disorders. Research developments in this area have revealed fundamental insights into the genes and molecular pathways that underlie neurological and psychiatric diseases. In a new series of review articles published by Cell Press in the October 21 issue of the journal Neuron, experts in the field discuss exciting recent advances in neurogenetics research and the potential implications for the treatment of these devastating disorders.

Our cells live ever on the verge of suicide, requiring the close attention of a team of molecules to prevent the cells from pulling the trigger. This self-destructive tendency can be a very good thing, as when dangerous precancerous cells are permitted to kill themselves, but it can also go horribly wrong, destroying brain cells that store memories, for instance.

BOSTON––Raising the survival rate of children with sarcoma in low-income countries will require steps to diagnose the disease sooner, train cancer pathologists, expand radiation therapy services, create multi-specialty teams to review each case, and other actions, according to an international study led by Dana-Farber/Children's Hospital Cancer Center researchers. The findings will be presented at the 42nd Congress of the International Society of Paediatric Oncology (SIOP) in Boston on Friday, Oct. 22.

Amid ongoing concern about plastic waste accumulating in municipal landfills, and reliance on imported oil to make plastics, scientists are reporting development of a new ultra-light biodegradable foam plastic material made from two unlikely ingredients: The protein in milk and ordinary clay. The new substance could be used in furniture cushions, insulation, packaging, and other products, they report in the ACS' Biomacromolecules, a monthly journal.

Scientists are reporting evidence that black rice — a little-known variety of the grain that is the staple food for one-third of the world population — may help soothe the inflammation involved in allergies, asthma, and other diseases. Their study appears in ACS' bi-weekly Journal of Agricultural and Food Chemistry.

CAMBRIDGE, Mass., Oct. 20, 2010 -- Microbes living at the bottom of the Gulf of Mexico may consume far more of the gaseous waste from the Deepwater Horizon oil spill than previously thought, according to research carried out within 100 miles of the spill site.

A paper on that research, conducted before the Deepwater Horizon rig exploded six months ago today, will appear in a forthcoming issue of the journal Deep-Sea Research II. It describes the anaerobic oxidation of methane, a key component of the Gulf oil spill, by microbes living in seafloor brine pools.

For the first time, researchers have discovered a disease mechanism that links hereditary amyotrophic lateral sclerosis to the more common "sporadic" form of ALS -- and points to a possible therapeutic target.

The findings are reported online in advance of publication in the journal Nature Neuroscience.

ALS is an adult-onset disease that causes progressive degeneration of motor neurons and death within three to five years of diagnosis.

UPTON, NY — Many studies have suggested that genetic differences make some individuals more susceptible to the addictive effects of alcohol and other drugs. Now scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory provide the first experimental evidence to directly support this idea in a study in mice reported in the October 19, 2010, issue of Alcoholism Clinical Experimental Research.

CHAPEL HILL – Researchers from the University of North Carolina at Chapel Hill School of Medicine have discovered a gene variant that may protect against alcoholism.

The variant, in a gene called CYP2E1, is associated with a person's response to alcohol. For the ten to twenty percent of people that possess this variant, those first few drinks leave them feeling more inebriated than the rest of the human population, who harbor a different version of the gene.

BOSTON (October 20, 2010) - People who consume several servings of whole grains per day while limiting daily intake of refined grains appear to have less of a type of fat tissue thought to play a key role in triggering cardiovascular disease and type 2 diabetes, a new study suggests. Researchers at the Jean Mayer USDA Human Nutrition Researcher Center on Aging (USDA HNRCA) at Tufts University observed lower volumes of Visceral Adipose Tissue (VAT) in people who chose to eat mostly whole grains instead of refined grains.