Body

High blood levels of the antioxidant alpha-carotene appear to be associated with a reduced risk of dying over a 14-year period, according to a report posted online today that will be published in the March 28 print issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Dual antiplatelet therapy—treatment with the medications clopidogrel and aspirin together to prevent blood clots—poses a clinically significant risk of hemorrhage that should be considered before prescribing, according to a report in the November 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

EDITOR'S PICK: Who is in your poo?

Working with mice and human patients, Eric Pamer, Carles Ubdea, and colleagues, at Memorial Sloan-Kettering Cancer Center, New York, have generated data that suggest that high-throughput DNA sequencing of bacteria in the gut could identify patients at high-risk of life-threatening bloodstream infection with the antibiotic-resistant bacterium vancomycin-resistant Enterococcus (VRE).

The U.S. death rate from congenital heart defects dropped 24 percent from 1999 to 2006 among children and adults, according to research reported in Circulation: Journal of the American Heart Association.

A congenital heart defect was the underlying cause of 27,960 deaths — an age-standardized rate of 1.2 deaths per 100,000 people — based on data from death certificates.

In a comparable study published in Circulation in 2001, deaths due to congenital heart defects dropped 39 percent from 1979 to 1997.

Since 1871, when Charles Darwin wrote The Descent of Man, it has been widely accepted that "Variability is the necessary basis for the action of selection." Variability is associated with the ability to adapt, which is clearly beneficial at a species level. But there is increasing evidence that genetic variability may also give rise to advantages at the level of the individual.

SALT LAKE CITY, November 22, 2010 —Researchers from Huntsman Cancer Institute (HCI) at the University of Utah report that they have identified a previously undiscovered trigger mechanism for a quality control checkpoint at the very end of the cell division process in a paper to be published in the November 29 issue of The Journal of Cell Biology and online today. This trigger mechanism monitors whether the cell's nucleus, where the DNA resides, has the proper structure and delays cell division if the structure is not correct.

Targeted breast ultrasound should be the primary imaging technique used to evaluate focal (confined) breast signs and symptoms in women younger than 30, according to a study in the December issue of the American Journal of Roentgenology (www.ajronline.org).

A sugar found in mouse breast milk promotes the generation of colitis in offspring, according to a study published online on November 22 in the Journal of Experimental Medicine (www.jem.org).

Boston, MA – A new study released today estimates that the global initiative to eradicate polio could provide net benefits of at least US$40-50 billion if transmission of wild polioviruses is interrupted within the next five years. The study provides the first rigorous evaluation of the benefits and costs of the Global Polio Eradication Initiative (GPEI)—the single largest project ever undertaken by the global health community.

There are 27 species of bats identified in the Basque Country today. Twenty years ago there were hardly any records. This data reflects the fruitful work on the ecology and behavioural development of bats by the University of the Basque Country (UPV/EHU) research team since the 90s. The director of the team, Mr Joxerra Aihartza, took the first steps when he began drawing up a complete atlas of the distribution of bat species in the Autonomous Community of the Basque Country (CAV-EAE). There are now nine biologists on the team.

Hospitals all over the world need to be aware of how to treat emergency blast injuries and military surgeons can provide valuable knowledge and advice to their civilian counterparts based on their experience of battlefield injuries. That is the driving force behind two papers published online by BJS, the British Journal of Surgery.

UPTON, NY — A study to be published as the "Paper of the Week" in the Journal of Biological Chemistry this December details how zinc, an element fundamental to cell growth, enters the cell via zinc-specific uptake proteins. The research, conducted at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory, is the first to purify this kind of protein and study its role in zinc uptake.

See it for yourself: a new breakthrough in imaging technology using a combination of light and sound will allow health care providers to see microscopic details inside the body. Access to this level of detail potentially eliminates the need for some invasive biopsies, but it also has the potential to help health care providers make diagnoses earlier than ever before—even before symptoms arise.

The link between sleeping and obesity is drawn tighter as a new research published online in the FASEB Journal (http://www.fasebj.org/content/early/2010/11/19/fj.10-172080.abstract) study shows that what your mother ate when she was pregnant may make you obese or overweight by altering the function of genes (epigenetic changes) that regulate circadian rhythm.

EAST LANSING, Mich. — Late-preterm babies – those born between 34 and 36 weeks – are at an increased risk for cognitive and emotional problems, regardless of maternal IQ or demographics, according to new research published by Michigan State University researchers in the current edition of the journal Pediatrics.