Body

– Symptomatic lumbar disc disease, a condition caused by degeneration or herniation of the discs of the lower spine, may be inherited, according to a new study published in the Journal of Bone and Joint Surgery (JBJS).

A team of wildlife experts led by UC Davis called today for a national fight against a new fungus that has killed more than 1 million bats in the eastern United States and is spreading fast throughout North America.

"If we lose bats, we lose keystone species in some communities, predators that consume enormous numbers of insects, and beautiful wildlife species that are important parts of North America's biodiversity," said Janet Foley, a UC Davis professor of veterinary medicine at the Center for Vectorborne Diseases.

Surgery to "deactivate" migraine headaches produces lasting good results, with nearly 90 percent of patients having at least partial relief at five years' follow-up, reports a study in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

In the search for life on Mars or any planet, there is much more than the presence of carbon and oxygen to consider. Using Earth's biogeochemical cycles as a reference point, elements like nitrogen, iron and sulfur are just as important for supporting life. As explored in studies published in February's open-access Special Issue of Frontiers in Ecology and the Environment, the most basic elements work together to support an extraordinary diversity of life.

TEMPE, Ariz. – Unraveling the molecular basis of life is an age-old quest of humanity. A breakthrough towards this goal was reported in a pair of studies published Feb. 3 in the scientific journal Nature, detailing a new method developed to determine structures of biomolecules based on diffraction from protein nanocrystals that are so small that they are not even visible under the microscope. A tiny aerojet nozzle provides a fully hydrated constant stream of nanocrystals, both supplied from an interdisciplinary research team at Arizona State University.

A new study takes advantage of genetic similarities between mammals and fruit flies by coupling a complex genetic screening technique in humans with functional validation of the results in flies. The new strategy, published by Cell Press on February 3rd in The American Journal of Human Genetics, has the potential to be an effective approach for unraveling genetically complex human disorders and providing valuable insights into human disease.

Ever since researchers devised a recipe for turning adult cells into cells that look and act like embryonic stem cells, there has been lingering doubt in the field about just how close to embryonic stem cells each of those cell lines really is at a molecular and functional level. Now, researchers reporting in the February 4th issue of the journal Cell, a Cell Press publication, have developed a systematic way to lay those doubts about quality to rest.

A new study sheds light on why individuals who inherit a particular family of mutations have a high risk of developing a very aggressive form of breast cancer. The research, published by Cell Press on February 4th in the journal Cell Stem Cell, shows that breast tissue cells from these individuals make abnormal cell-fate decisions even before cancer develops and provides exciting new insights into the mechanisms behind one of the most lethal types of breast cancer.

BLOOMINGTON, Ind. -- Complexity ever in the eye of its beholders, the animal with the most genes -- about 31,000 -- is the near-microscopic freshwater crustacean Daphnia pulex, or water flea. By comparison, humans have about 23,000 genes. Daphnia is the first crustacean to have its genome sequenced.

The potentially deadly bacterium Salmonella possesses a molecular machine that marshals the proteins it needs to hijack cellular mechanisms and infect millions worldwide.

In a paper published Feb. 3 online in Science Express, Yale University researchers describe in detail how Salmonella, a major cause of food poisoning and typhoid fever, is able to make these proteins line in up in just the right sequence to invade host cells.

The worldwide prevalence of obesity has nearly doubled since 1980, according to a major study on how three important heart disease risk factors have changed across the world over the last three decades. The study, published today in three papers in the Lancet, looked at all available global data to assess how body mass index, blood pressure and cholesterol changed between 1980 and 2008.

The human body has a remarkable ability to heal itself. Due to the presence of dedicated stem cells, many organs can undergo continuous renewal. When an organ becomes damaged, stem cells in the organ are typically activated, producing new cells to regenerate the tissue. This activity of stem cells, however, has to be carefully controlled, as too much stem cell activity can cause diseases like cancer. Current research in stem cell biology is starting to unravel the control mechanisms that maintain a balance between efficient regeneration and proper control of stem cell function.

Cold Spring Harbor, N.Y. – A constellation of different stem cell populations within our skin help it to cope with normal wear and tear. By constantly proliferating, the stem cells allow skin to replenish itself, allowing each cell to be replaced by a new one about once a month. But the normal cycle of division and death within one or more of these stem cell types can sometimes be derailed by genetic mishaps. Such events are believed to spawn carcinomas and other deadly skin cancers, which are the mostly frequently diagnosed cancers in the United States.

Surprising new evidence which overturns current theories of how humans colonised the Pacific has been discovered by scientists at the University of Leeds, UK.

The islands of Polynesia were first inhabited around 3,000 years ago, but where these people came from has long been a hot topic of debate amongst scientists. The most commonly accepted view, based on archaeological and linguistic evidence as well as genetic studies, is that Pacific islanders were the latter part of a migration south and eastwards from Taiwan which began around 4,000 years ago.

A new, wide-ranging survey that compares the past and present condition of oyster reefs around the globe finds that more than 90 percent of former reefs have been lost in most of the "bays" and ecoregions where the prized molluscs were formerly abundant. In many places, such as the Wadden Sea in Europe and Narragansett Bay, oysters are rated "functionally extinct," with fewer than 1 percent of former reefs persisting. The declines are in most cases a result of over-harvesting of wild populations and disease, often exacerbated by the introduction of non-native species.