Body

Infants exposed to HIV at birth but not infected may have lower antibody levels

CHICAGO – In a study that included infants from South Africa, those who were exposed to human immunodeficiency virus (HIV) at birth but did not become infected had lower levels of antibodies to diseases such as pertussis, tetanus and pneumococcus, compared to infants of non-HIV infected mothers, according to a study in the February 9 issue of JAMA.

Male cancer survivor offspring slightly higher risk of congenital birth abnormalities

The incidence of major congenital birth abnormalities was slightly higher in the offspring of male cancer survivors compared with children of fathers with no history of cancer, according to a study published online February 8th in the Journal of the National Cancer Institute.

Increased levels of cardiac enzymes after heart bypass associated with increased mortality

Researchers at Mount Sinai School of Medicine have found that even small amounts of damage to heart muscle during coronary artery bypass grafting (CABG) is associated with an increased risk of death, even among patients who initially do well following surgery. The study is published in the February 9 issue of the Journal of the American Medical Association (JAMA).

Study suggests why HIV-uninfected babies of mothers with HIV might be more prone to infections

Babies whose mothers have HIV, but who are not HIV-infected themselves, are born with lower levels of specific proteins in their blood called antibodies, which fight infection, compared with babies not exposed to HIV, a new study has found. The finding, published today in the Journal of the American Medical Association, might explain in part why uninfected babies born to women with HIV have a higher risk of illness and death early in life.

New techniques for stapling peptides could spur development of drugs for cancer

BUFFALO, N.Y. -- Researchers at the University at Buffalo have devised two new ways of "stapling" peptide helices to prevent these medically important molecules from losing their shape and degrading in the presence of enzymes.

The discovery could help speed the development of peptide-based drugs against diseases including cancer. UB scientists say the methods they pioneered are simpler than existing techniques, one of which employs an expensive ruthenium catalyst to connect chemical side chains that protrude from the main body of helical peptides.

Scientists develop method to identify fleetingly ordered protein structures

LA JOLLA, CA – February 8, 2011 - A team of scientists from The Scripps Research Institute and the University of California, San Diego (UCSD) have developed a novel technique to observe previously unknown details of how folded structures are formed from an intrinsically disordered protein. The insights could help scientists to better understand the mechanism of plaque formation in neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

Detecting pathogens in waterways: An improved approach

U.S. Department of Agriculture (USDA) scientists have come up with a way to detect pathogenic Escherichia coli and Salmonella bacteria in waterways at lower levels than any previous method. Similar methods have been developed to detect pathogenic E. coli in meat products, but the approach by the scientists with USDA's Agricultural Research Service (ARS) represents a first for waterways.

ARS is USDA's principal intramural scientific research agency, and this research supports the USDA priority of ensuring food safety.

Why leatherback turtles linger in South Pacific Gyre, and why it matters

Leatherbacks. They are the Olympians of the turtle world – swimming farther, diving deeper and venturing into colder waters than any other marine turtle species. But for all their toughness, they have still suffered a 90 percent drop in their population in the eastern Pacific Ocean over the last 20-plus years, largely at the hands of humanity.

Study shows delayed-enhancement MRI may predict, prevent strokes

SALT LAKE CITY, Feb. 8, 2011 – Researchers at the University of Utah's Comprehensive Arrhythmia and Research Management (CARMA) Center have found that delayed-enhancement magnetic resonance imaging (DE-MRI) holds promise for predicting the risks of strokes, the third leading cause of death in the U.S. Their latest study on a novel application of this technology appears in the Feb. 15 issue of the Journal of the American College of Cardiology.

Turning bacteria against themselves

Bacteria often attack with toxins designed to hijack or even kill host cells. To avoid self-destruction, bacteria have ways of protecting themselves from their own toxins.

Now, researchers at Washington University School of Medicine in St. Louis have described one of these protective mechanisms, potentially paving the way for new classes of antibiotics that cause the bacteria's toxins to turn on themselves.

Quality varies in social networking websites for diabetics

Boston, Mass. – Nearly one-half of U.S. adults who use the Internet participate in social networks. While these increasingly include health-focused networks, not much is known about their quality and safety. In one of the first formal studies of social networking websites targeting patients, researchers in the Children's Hospital Boston Informatics Program performed an in-depth evaluation of ten diabetes websites.

Polar bear births could plummet with climate change

University of Alberta researchers Péter Molnár, Andrew Derocher and Mark Lewis studied the reproductive ecology of polar bears in Hudson Bay and have linked declining litter sizes with loss of sea ice.

The researchers say projected reductions in the number of newborn cubs is a significant threat to the western Hudson Bay polar-bear population, and if climate change continues unabated the viability of the species across much of the Arctic will be in question.

Single-cell marine predator's unique survival mechanisms revealed: UBC research

University of British Columbia researchers have uncovered the unique survival mechanisms of a marine organism that may be tiny, but in some ways has surpassed sharks in its predatory efficiency.

Published today in the journal Nature Communications, the research team's portrait of the microscopic dinoflagellate Oxyrrhis marina reveals a predator so efficient that it has even acquired a gene from its prey.

The most genes in an animal? Tiny crustacean holds the record

Scientists have discovered that the animal with the most genes--about 31,000--is the near-microscopic freshwater crustacean Daphnia pulex, or water flea.

By comparison, humans have about 23,000 genes. Daphnia is the first crustacean to have its genome sequenced.

Wolverines threatened by climate change, earlier springs

The aggressive wolverine may not be powerful enough to survive climate change in the contiguous United States, new research concludes.

Wolverine habitat in the northwestern United States is likely to warm dramatically if society continues to emit large amounts of greenhouse gases, according to new computer model simulations carried out at the National Center for Atmospheric Research (NCAR) in Boulder, Colo.