Body

From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950's. Now, with the work being done in Jeff Gelles' Lab at Brandeis University, researchers have developed a way to use lasers to study the splicing of pre-messenger RNA molecules, an essential process in creating proteins to sustain advanced organisms, including human life. This process of splicing is carried out by a cellular micro-machine called the spliceosome.

Illicit drug users are at increased risk of being exposed to microbial pathogens and are more susceptible to serious infections say physicians writing in the Journal of Medical Microbiology. The review, which aims to improve the microbiological diagnosis of drug use-related infections, assesses the role of drug related practices in the spread of a range of bacterial, viral, fungal and protozoal infections.

March 10, 2011 – A detailed analysis of gene fusions present at high frequency in the most common pediatric brain tumors has been performed for the first time in a study published online today in Genome Research (www.genome.org), shedding new light on how these genomic rearrangements form in the early stages of cancer.

Boston, MA – A team of researchers at Brigham and Women’s Hospital (BWH) have found that approximately one out of every twelve adult smokers have abnormal lung densities present on chest computed tomography (CT) images suggestive of interstitial lung disease which is associated with substantial reductions in lung volumes. In addition, despite being positively associated with smoking, these lung densities were inversely not associated with emphysema. This research is published online on March 10th in the New England Journal of Medicine.

A strong international collaboration and a single patient with mild muscle disease and severe cognitive impairment have allowed University of Iowa researchers to identify a new gene mutation that causes muscular dystrophy.

Pregnant non-smokers who breathe in the second-hand smoke of other people are at an increased risk of delivering stillborn babies or babies with defects, a study led by researchers at The University of Nottingham has found.

The study, published in the April edition of the journal Pediatrics, found passive smoking increased the risk of still birth by almost one-quarter (23 per cent) and was linked to a 13 per cent increased risk of congenital birth defects.

DALLAS – March 10, 2011 – Researchers at UT Southwestern Medical Center have identified a chemical compound that may eventually lead to a drug that fights cancers that are dependent on a particular anti-viral enzyme for growth.

The researchers are testing the compound's effectiveness at fighting tumors in mice. If it is successful, they will then work to develop a drug based on the compound to combat pancreatic and non-small cell lung cancer, two cancer types in which this particular enzyme, TBK-1, often is required for cancer cell survival.

U.S. researchers who collaborate with international scientists are more likely to have their work cited than peers who do not utilize overseas expertise, according to a new study released this week by Rice University's Baker Institute for Public Policy. U.S. collaborators with international scientists are also more likely to receive greater recognition and produce work with greater impact.

GAINESVILLE, Fla. — A new study led by a University of Florida researcher uses tracking data of three shark species to provide the first evidence some of the fish swim directly to targeted locations.

Researchers found tiger and thresher sharks showed the ability to orient at large distances, with tiger sharks swimming in direct paths at least 4 miles away and reaching specific resource areas about 30 miles away, said lead author Yannis Papastamatiou, a marine biologist in the division of ichthyology at the Florida Museum of Natural History on the UF campus.

Chemotherapy drug resistance contributes to treatment failure in more than 90 percent of metastatic cancers. Overcoming this hurdle would significantly improve cancer survival rates.

Dean Ho, an associate professor of biomedical engineering and mechanical engineering at Northwestern University, believes a tiny carbon particle called a nanodiamond may offer an effective drug delivery solution for hard-to-treat cancers.

Satellites have been busy this week covering severe weather across the U.S. Today, the GOES-13 satellite and NASA's Aqua satellite captured an image of the huge stretch of clouds associated with a huge and soggy cold front as it continues its slow march eastward. Earlier this week, NASA's Tropical Rainfall Measuring Mission satellite captured images of severe weather that generated tornadoes over Louisiana.

International Panel Revises "McDonald Criteria" for Diagnosing MS -- Use of new data should speed diagnosis -- Publication coincides with MS Awareness Week

CAMBRIDGE, Mass. -- In the fall of 1917, a new strain of influenza swirled around the globe. At first, it resembled a typical flu epidemic: Most deaths occurred among the elderly, while younger people recovered quickly. However, in the summer of 1918, a deadlier version of the same virus began spreading, with disastrous consequence. In total, the pandemic killed at least 50 million people — about 3 percent of the world's population at the time.

STANFORD, Calif. — Humans are clearly different from chimpanzees. The question is, why? According to researchers at the Stanford University School of Medicine, it may boil down in part to what we don't have, rather than what we do. The loss of snippets of regulatory DNA, the scientists found, could be the reason why, for example, humans lack the penile spines found in many other mammals, and also why specific regions of our brains are larger than those of our closest relatives.

(MEMPHIS, Tenn. – March 9, 2011) Despite dramatically improved survival rates for childhood acute lymphoblastic leukemia (ALL), relapse remains a leading cause of death from the disease. Work led by St. Jude Children's Research Hospital investigators identified mutations in a gene named CREBBP that may help the cancer resist steroid treatment and fuel ALL's return.