Eurekalert

Every drug starts with the search for an active substance targeting disease-related key players. However, there is no perfect drug that affects the one target: no effect without side effects. A group led by Prof. Herbert Waldmann and Dr. Slava Ziegler at the Max Planck Institute of Molecular Physiology in Dortmund has now identified an unexpected effect for a group of characterized active substances: they all modulate cholesterol metabolism, a home-made problem, as it seems.

Replication of SARS-CoV-2, the virus responsible for COVID-19, depends on a series of interactions between viral proteins and different cellular partners such as nucleic acids (DNA or RNA). Characterizing these interactions is crucial to elucidate the process of viral replication and identify new drugs for treating COVID-19.

A new study led by researchers from the University of Chicago shows that deep learning models trained on large sets of cancer genetic and tissue histology data can easily identify the institution that submitted the images.

Over the last few decades, neurodegenerative diseases became one of the top 10 global causes of death. Researchers worldwide are making a strong effort to understand neurodegenerative diseases pathogenesis, which is essential to develop efficient treatments against these incurable diseases. A team of researchers found out the implication of lysosomes in the spread of Parkinson's disease.

An international physics team with the participation of the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) has proposed a new concept that may allow selected cosmic extreme processes to be studied in the laboratory in the future. A special setup of two high-intensity laser beams could create conditions similar to those found near neutron stars, for example. An antimatter jet is generated and accelerated very efficiently, as the experts report in the journal Communications Physics (DOI: 10.1038/s42005-021-00636-x).

Scientists at Cambridge and Leeds have successfully reversed age-related memory loss in mice and say their discovery could lead to the development of treatments to prevent memory loss in people as they age.

In what may be the largest survey of physician attitudes about firearms and how firearm-owning surgeons store guns in their homes, U.S. members of the American College of Surgeons (ACS) said they support the organization taking an active role in advocating for policies and programs designed to lower the risk of firearm-related injuries and deaths.

German researchers have developed a novel therapeutic approach for resuscitation after cardiac arrest that allows much higher success rates than before - often without neurological complications / Study in Nature Reviews Neuroscience summarizes decisive factors / New „heart-lung machine" makes clinical implementation possible.

After examining nearly the entire human genome for genetic changes that increase risk of aneurysm, researchers discovered a new change in the genetic code of a transcription factor.

International consortium, including then IGC, now current ITQB NOVA PI and GREEN-IT member Jörg Becker, offers novel insight into the reproductive evolution of land plants, in new study published in Nature Plants.

A new survey of our home galaxy, the Milky Way, combines the capabilities of the Very Large Array and the Effelsberg telescope in Germany to provide astronomers with valuable new insights into how stars much more massive than the Sun are formed.

The chequered history of the Cambro-Ordovician Alum Shale in northern Europe offers insights into oil and gas formation and traces of life on Mars.

Transplanting hematopoietic stem cells to treat cancers and other conditions carries with it the risk of developing cardio-cerebrovascular diseases (CCVD)--disorders affecting the blood vessels of the heart and brain. Although research on post-transplant CCVD is extensive, there is paucity of knowledge on the effects of pre-transplant CCVD on transplant outcomes. Now researchers in China suggest pre-transplant CCVD indirectly affects patient mortality and survival following transplant through their strong association with post-transplant CCVD.

In a new publication from Opto-Electronic Advances; DOI 10.29026/oea.2021.200030 , Researchers led by Professor Liu Yan from Xidian University, China and Professor Gan Xuetao from Northwestern Polytechnical University, China consider generation and application of the high-Q resonance in all-dielectric metasurfaces.

Jiachen Lin, Harvard School of Dental Medicine, Boston, Mass., USA., presented the poster "Burden of Oral Diseases in Emerging Countries: A Prediction Model" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021.

An international team of scientists has reported strong indications of freshened groundwater offshore the coastline between Valletta and Marsascala, in the south-east of Malta.

Alexandria, Va., USA - Iain Chapple, University of Birmingham, England, presented the oral session "Longitudinal Serological and Vaccination Responses to SARS-COV-2 in Dental Professionals" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021.

Xingying Qi, West China Hospital of Stomatology, Sichuan University, Chengdu, China, presented the oral session "Cannabidiol Promotes Oral Ulcer Healing by Inactivating CMPK2-Mediated NLRP3 Inflammasome" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021.

More than 820 million people in the world don't have enough to eat, while climate change and increasing competition for land and water are further raising concerns about the future balance between food demand and supply. The results of a new IIASA-led study can be used to benchmark global food security projections and inform policy analysis and public debate on the future of food.

Research led by Queen Mary University of London provides new insight into the mechanisms that lead to uncontrolled inflammation in COVID-19 patients.