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Russian and Ukrainian scientists have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies -- among pest control chemicals. In addition, the team looked at modifications of the medication called hymecromone, deeming them promising for anti-fibrotic drugs, too. Published in Glycobiology, the study also sheds light on the possible mechanism of action of the investigated compounds, all of which inhibit the synthesis of hyaluronic acid.

Older people affected by memory loss have much to gain from AR technology, yet a study from the University of Bath in the UK exploring the use of augmented reality to support older adults at home finds the user interface is sometimes confusing for those aged 50+.

Until relatively recently, opioids were a mainstay of treatment for pain following total hip or knee replacement. Today, a growing body of evidence supports the use of multimodal analgesia - combinations of different techniques and medications to optimize pain management while reducing the use and risks of opioids, according to a paper in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

What happens when climate change affects the abundance and distribution of fish? Fishers and fishing communities in the Northeast United States have adapted to those changes in three specific ways, according to new research published in Frontiers in Marine Science.

New research from Aarhus BSS at Aarhus University shows that openness about the effectiveness and side effects of vaccines bolster confidence in the health authorities, and this is a crucial factor if we are to defeat the coronavirus pandemic.

Populist anti-foreign aid rhetoric works - but only fans of populist politicians are convinced by hostile messages about charity abroad, a new study shows. Those who distrust populist politicians are significantly less susceptible to these messages.

Coastal wetlands - such as salt marshes - provide even more flood protection than previously thought, reducing risks to lives and homes in estuaries, a new study reveals. Research showed that wetlands that grow in estuaries can reduce water levels by up to 2 metres and provide protection far inland.This saved up to $38 (£27) million in avoided flood damage costs per estuary during a large storm thanks to the wetlands' role.

Seismic waves passing through the ground near Longyearbyen in the Adventdalen valley, Svalbard, Norway have been slowing down steadily over the past three years, most likely due to permafrost warming in the Arctic valley.

Though writing by hand is increasingly being eclipsed by the ease of computers, a new study finds we shouldn't be so quick to throw away the pencils and paper: handwriting helps people learn certain skills surprisingly faster and significantly better than learning the same material through typing or watching videos.

What connection could possibly exist between the stripes on tropical fish and crystal growth? The answer is the way in which order emerges from randomness through Turing patterns, according to what a research team led by Dr. Fuseya of the University of Electro-Communications, Japan, has recently found. After analyzing a mysterious striped pattern, they observed while trying to grow a monoatomic layer of bismuth, they showed that Turing patterns also exist at the nanoscale.

Researchers from The University of Texas MD Anderson Cancer Center found specific intestinal microbiota signatures correlate with high-grade adverse events and response to combined CTLA-4 and PD-1 blockade treatment.

A research team at Washington University School of Medicine in St. Louis has identified potential new treatment targets for Alzheimer's disease, as well as existing drugs with therapeutic potential.

What The Study Did: A decline in COVID-19 cases after the vaccination of health care workers in a region of California that experienced high rates of COVID-19 disease over the winter is reported in this single-center study.

Tumor fragments in the lab are able to predict whether the corresponding real-life patients will benefit from immunotherapy. "We've solved a major problem many scientists had been facing: preserving a tumors original composition and structure outside of the patient in the lab", says cancer researcher Daniela Thommen from the Netherlands Cancer Institute. On 8 July, the results of her study are published in Nature Medicine.

What The Study Did: The SARS-CoV-2 BNT162b2 (Pfizer-BioNTech) vaccine appeared to be safe and achieve satisfactory serologic status in patients with cancer. While there was a lag in antibody production compared with the rate in the noncancer control group, seroconversion occurred in most patients after the second dose.

A global consortium of scientists investigated which genetic factors influence severity of COVID-19. They found 13 locations in the human genome that are strongly associated with infection or severe COVID-19. They also identified causal factors such as smoking and high BMI. This study, one of the largest GWASs ever performed, includes nearly 50,000 COVID-19 patients and two million uninfected controls.

Researchers from Qatar, alongside researchers from 24 other countries, contributed to the COVID-19 Host Genetics Initiative large analysis identifying genetic markers for COVID risks, published today in Nature. The results of the analysis will enable genetic tests to predict the course of the disease, potential targeted therapies and drug repurposing to treat new infections and "long COVID". It is the latest milestone establishing Qatar as a leading regional center for genomics research and precision medicine.

As atmospheric concentrations of CO2 continue to rise, we are putting future generations at risk of having to deal with a massive carbon debt. IIASA researchers and international colleagues are calling for immediate action to establish responsibility for carbon debt by implementing carbon removal obligations, for example, during the upcoming revision of the EU Emissions Trading Scheme.

MIT researchers have devised a way to protect seeds from the stress of water shortage during their crucial germination phase, and even provide the plants with extra nutrition. Simple and inexpensive, the process could be deployed in arid regions to facilitate agriculture on drought-stressed land.

Researchers from Brigham and Women's Hospital and collaborators developed a new brain mapping approach that may help clarify the cause of a variety of neuropsychiatric conditions and identify promising stimulation sites to target therapeutically.