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Electrons riding a double wave
An international research group has now made significant progress in the further development of compact plasma accelerators, considered a promising technology for the future: With two complementary experiments at HZDR and LMU, the team was able to combine two different plasma technologies for the first time and build a novel hybrid accelerator. The concept could advance accelerator development and, in the long term, become the basis of highly brilliant X-ray sources for research and medicine.
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Alterations in the 3D genome structure and effects on fertility revealed
A study led by scientists at the UAB and conducted with mice models reveals how chromosomal reorganizations alter the genome's three-dimensional organisation in germ cells. The study, published in Nature Communications, opens new research paths into the genetic origin of infertility.
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We know the cost of free choice and locality - in physics and not only
Do we have free choice or are our decisions predetermined? Is physical reality local, or does what we do here and now have an immediate influence on events elsewhere? The answers to these questions are sought by physicists in the Bell inequalities. It turns out that free choice and local realism can be skilfully measured and compared. The results obtained reveal surprising relationships of a fundamental and universal nature, going far beyond quantum mechanics itself.
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Young orangutans have sex-specific role models
Social learning in orangutans is shaped by their sex. Young males learn their foraging skills from immigrant individuals, while young females get their skills by observing their mothers and other residents in the area. These different sets of ecological knowledge help secure their survival.
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Across US, COVID-19 death rate higher for those with IDD
The COVID-19 death rate for people with intellectual and developmental disabilities (IDD) is higher than the general population in several states across the U.S., according to a new study published in Disability and Health Journal.
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Immune genetics and previous common cold infections might help protect Japan from COVID-19
By meta-analysis, experimentally determined COVID-19 virus T cell epitopes were compared with sequences of common cold coronaviruses (CCCoVs). Only one CCCoV-matching epitope was repeatedly identified as highly immunogenic, namely the CD8+ T cell epitope VYIGDPAQL ("VYI" peptide) if presented by the MHC class I allele HLA-A*24:02. Approximately 60% of Japanese individuals carry this allele, which in combination with previous CCCoV infections might help explain the surprisingly low prevalence of COVID-19 in Japan.
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Challenging the standard model of cancer
In spite of decades of research, cancer remains an enigma. Conventional wisdom holds that cancer is driven by random mutations that create aberrant cells that run amok in the body. In a new paper published this week in the journal BioEssays, Arizona and Australian researchers challenge this model by proposing that cancer is a type of genetic throwback, that progresses via a series of reversions to ancestral forms of life.
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Medicare negotiation could save businesses $195 billion and workers another $98 billion
A new analysis conducted by the West Health Policy Center and released by its Council for Informed Drug Spending Analysis (CIDSA) estimates that the Elijah E. Cummings Lower Drug Costs Now Act (H.R. 3) could result in hundreds of billions of dollars in lower commercial health insurance costs by 2030.
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From mice to men: Study reveals potential new target for treating acute myeloid leukemia
A study released in STEM CELLS indicates that blocking transforming growth factor beta 1 (TGFβ1) could improve hematopoiesis in patients with acute myeloid leukemia.
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Two complete responses and response rate of 41% for people with synovial sarcoma reported at ASCO in Adaptimmune's phase 2 SPEARHEAD-1 trial
Adaptimmune Therapeutics plc (Nasdaq:ADAP), a leader in cell therapy to treat cancer, will report initial data from its Phase 2 SPEARHEAD-1 trial, with afamitresgene autoleucel (afami-cel, formerly ADP-A2M4), at the American Society of Clinical Oncology (ASCO) congress.
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Global food, hunger challenges projected to increase mortality, disability by 2050
A new study shows that population and climate change will exacerbate the challenge of meeting nutrition and food needs over the next 30 years, especially in Africa south of the Sahara, but also that increased investment of $25.5 billion annually would more than offset the negative impacts of climate change.
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Less forest, more species
Normally, mountain forests are among the most diverse habitats in alpine regions. Yet, as a team from the Alfred Wegener Institute discovered in the Tibetan Plateau, the higher, treeless areas are home to far more species.
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Moon mission delays could increase risks from solar storms
Although patterns in the timing of moderate space weather events are known, the most extreme and dangerous events were thought to be random in their timing. This study found for the first time that extreme space weather occurs most frequently at predictable times during solar cycles, meaning space missions could be timed to avoid them.
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Technique uses fluctuations in video pixels to measure energy use of developing embryos
Researchers at the University of Plymouth have developed a cutting edge technique which enables them to instantly examine the biological traits and behaviours of developing embryos as an energy signature, rather than focusing on individual characteristics
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Oncotarget: The comprehensive genomic profiling test, GEM ExTra®
Proprietary bioinformatics, paired with comprehensive clinical curation results in reporting that defines clinically actionable, FDA-approved, and clinical trial drug options for the management of the patient's cancer.
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New tool factors effects of fossil-fuel emissions on ocean research
A newly developed tool will allow scientists to better gauge how centuries of fossil fuel emissions could be skewing the data they collect from marine environments. Researchers at the University of Alaska Fairbanks led the effort, which created a way for marine scientists to factor into their results the vast amounts of anthropogenic carbon dioxide that are being absorbed by oceans.
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Walking in their shoes: Using virtual reality to elicit empathy in healthcare providers
Research has shown empathy gives healthcare workers the ability to provide appropriate supports and make fewer mistakes. This helps increase patient satisfaction and enhance patient outcomes, resulting in better overall care. In an upcoming issue of the Journal of Medical Imaging and Radiation Sciences, published by Elsevier, multidisciplinary clinicians and researchers from Dalhousie University performed an integrative review to synthesize the findings regarding virtual reality (VR) as a pedagogical tool for eliciting empathetic behavior in medical radiation technologists (MRTs).
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Red meat intake, poor education linked to colorectal cancer
A new paper in JNCI Cancer Spectrum indicates that several non-genetic factors--including greater red meat intake, lower educational attainment, and heavier alcohol use--are associated with an increase in colorectal cancer in people under 50.
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Does correcting online falsehoods make matters worse?
Attempting to politely correct misinformation on Twitter can have negative consequences, leading to even less-accurate tweets and more toxicity from the people being corrected, according to a study co-authored by MIT scholars.
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Blocking a protein in liver cells protects against insulin resistance, fatty liver disease
A new multi-institution study led by a team of researchers at the David Geffen School of Medicine demonstrated that blocking a protein called ABCB10 in liver cells protects against high blood sugar and fatty liver disease in obese mice. Furthermore, ABCB10 activity prompted insulin resistance in human liver cells.
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