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Study finds mechanism leading to herceptin resistance and Rx approach to reverse it

Eurekalert - May 13 2021 - 00:05
Research conducted by an international team of scientists discovered a mechanism that leads to Herceptin resistance, representing a significant clinical obstacle to successfully treating HER2-positive breast cancer. They also identified a new approach to potentially overcome it.
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Urban traffic noise causes song learning deficits in birds

Eurekalert - May 13 2021 - 00:05
Zebra finches also suffer from a suppressed immune function due to the chronic stress.
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A new polarized fluorescent probe for revealing architectural dynamics of living cells

Eurekalert - May 13 2021 - 00:05
Researchers from TMDU, collaborating with scientists from MBL and RIKEN, developed a new probe, POLArIS, for real-time live-cell imaging that reveals the orientation of molecules and is expected to be applicable to a wide range of cell types and specimens. They tested POLArIS in starfish early embryos and discovered the existence of a new F-actin cellular architecture, FLARE, extending alongside the astral microtubules to the cell cortex. This may provide answers to some of the most fundamental questions regarding cell division.
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Can the diffraction limit overcome in the linear imaging system?

Eurekalert - May 13 2021 - 00:05
Spatial-frequency-shift microscopy with evanescent wave illumination shows intriguing advantages, including a large field of view, high speed, and good modularity. However, a missing band in the spatial frequency domain hampers the spatial-frequency-shift superresolution microscopy from achieving resolution better than 3 folds of the Abbe diffraction limit. Recently researchers at Zhejiang University have proposed chip-compatible wide-field 3D nanoscopy through tunable spatial frequency shift effect, making the diffraction limit overcome in the linear optical imaging system.
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Study: Obesity slows progress against cancer deaths

Eurekalert - May 13 2021 - 00:05
Study by UNC Gillings School of Global Public Health suggests that heart disease and obesity-associated cancer mortality rates have continued to improve, but at a slowing pace.
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Novel nanotech improves cystic fibrosis antibiotic by 100,000-fold

Eurekalert - May 13 2021 - 00:05
World-first nanotechnology developed by the University of South Australia could change the lives of thousands of people living with cystic fibrosis (CF) as groundbreaking research shows it can improve the effectiveness of the CF antibiotic Tobramycin, increasing its efficacy by up to 100,000-fold.
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Pandemic stigma: Foreigners, doctors wrongly targeted for COVID-19 spread in India

Eurekalert - May 13 2021 - 00:05
Accurate and focused information about COVID-19 from credible sources reduces stigmatisation and stress, according to a world-first study led by Monash University. Foreigners, minorities, police and frontline workers were blamed for spreading the virus in India. The study was conducted during the first wave of the virus. Researchers say elements of stigmatisation are still valid as India battles a tragic second wave.
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Scientists show how to attack the 'fortress' surrounding pancreatic cancer tumors

Eurekalert - May 13 2021 - 00:05
Tackling the scar tissue that shields pancreatic tumours from effective drug access is a promising advance in a notoriously hard-to-treat cancer.
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Non-linear optics meets X-rays

Eurekalert - May 13 2021 - 00:05
The recent advent of femtosecond X-ray sources offers unprecedented opportunities for structural and dynamical studies. It requires, however, manipulating spectral properties, as commonly done by non-linear optics at visible/infrared wavelengths. Here we show the first evidence for Self-Phase Modulation, a key non-linear effect in ultrafast laser science, in the soft X-Rays. Building on such effect, we demonstrate how to tune spectral properties in this wavelength region critical for core electrons pump-probe spectroscopy and nanoimaging.
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Freeform imaging systems: Fermat's principle unlocks 'first time right' design

Eurekalert - May 13 2021 - 00:05
Researchers at Brussels Photonics, Vrije Universiteit Brussel, have developed a 'first time right' design method that eliminates the "step-and-repeat" and "trial-and-error" approach in optical system design. They demonstrated the systematic, deterministic, scalable, and holistic character of their disruptive technique with various freeform lens- and mirror-based high-end examples and invite optical designers to experience their new method hands-on via an open-access trial web application.
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Snakes alive? We're totally fine with them -- just not at our house

Eurekalert - May 13 2021 - 00:05
The first study to analyze snake removals in a social-ecological context was recently published by an Arizona State University conservation biologist working with a local rattlesnake removal company."I think one of the surprises was that people don't hate snakes," said researcher Heather Bateman of the College of Integrative Sciences and Arts. "A lot of them responded that the snakes are important to the desert ecosystem and the snake belongs in the desert, just not in my garage."
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Eating more fruit and vegetables linked to less stress - study

Eurekalert - May 13 2021 - 00:05
Eating a diet rich in fruit and vegetables is associated with less stress, according to new research from Edith Cowan University (ECU). The findings revealed people who ate at least 470 grams of fruit and vegetables daily had 10 per cent lower stress levels than those who consumed less than 230 grams.
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Ion-selective smart porous membranes

Eurekalert - May 13 2021 - 00:05
A research group has developed an ion-selective smart porous membrane that can respond to outer stimuli, potentially paving the way for new applications in molecular separation and sensing applications.
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New study reveals where memories of familiar places are stored in the brain

Eurekalert - May 13 2021 - 00:05
As we move through the world, what we see is seamlessly integrated with our memory of the broader spatial environment. How does the brain accomplish this feat? A new study from Dartmouth College reveals that three regions of the brain in the posterior cerebral cortex, which the researchers call "place-memory areas," form a link between the brain's perceptual and memory systems. The findings are published in Nature Communications.
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Ankle and foot bone evolution gave prehistoric mammals a leg up

Eurekalert - May 13 2021 - 00:05
The evolution of ankle and foot bones into different shapes and sizes helped mammals adapt and thrive after the extinction of the dinosaurs, a study suggests.
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CDEX listens to the sound of cosmology from a laboratory deep underground

Eurekalert - May 13 2021 - 00:05
China Dark Matter Experiment (CDEX) collaboration presents weakly interacting massive particles (WIMPs) search results performed using two approaches of effective field theory, based on the data from both CDEX-1B and CDEX-10 stages. In the non-relativistic effective field theory and chiral effective field theory approach, analyses were applied to CDEX data to set new limits for the couplings of WIMP-nucleon effective operators and WIMP-pion scattering cross section.
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Abortion opposition related to beliefs about fetal pain perception

Eurekalert - May 13 2021 - 00:05
A person's stance on abortion is linked to their, often inaccurate, belief about when a fetus can feel pain, a University of Otago study has found.
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'Love thy neighbor, mask up' resonates among white evangelicals

Eurekalert - May 13 2021 - 00:05
White evangelicals are best persuaded to mask up through messages that stress the Christian doctrine of "love thy neighbor," according to a UCR-authored study published Tuesday. The study yielded a second effective way to persuade white evangelicals - but only if they are Republican. That is, messaging from former President Donald Trump that aligns mask-wearing with patriotism. The lessons learned from the study can be borrowed for pro-vaccine messaging, authors say.
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Teaching a computer program to track cells

Eurekalert - May 13 2021 - 00:05
Scientists at Gladstone Institutes have developed such an approach using "neural nets"--artificial intelligence programs that can detect patterns--to analyze the locations of hundreds of cells growing together in a colony. When they applied the technique to a group of stem cells, the program revealed that a small number of cells act as "leaders," able to direct the movements of their neighbors.
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Kaiser Permanente cancer survival rate higher among insured

Eurekalert - May 13 2021 - 00:05
Among cancer patients with health coverage in Southern California, those who were diagnosed and treated at Kaiser Permanente, an integrated health care organization, had better survival rates, especially Black and Latino patients, according to Kaiser Permanente research published in The American Journal of Managed Care.
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