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Anti-cancer immunotherapy drug with reduced side effects and increased therapeutic effects
To tackle this issue, a research team led by Dr. Ju Hee Ryu of the Center for Theragnosis at the Korea Institute of Science and Technology (KIST) has developed an anti-cancer prodrug that can improve anti-cancer immunotherapy by reacting only with cancer cells, thereby minimizing the toxicity to normal cells, including immune cells, and boosting patient immunity.
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Oncotarget: Treatment outcomes in patients with advanced hepatocellular carcinoma
In CTP class A patients, IGF/CTP score B was associated with shorter PFS and OS
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Oncotarget: Predicting clinical outcomes using cancer progression associated signatures
The P142 panel of metrics successfully predicted cancer progression status in patients with some, but not all cancer types analyzed.
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Oncotarget: Novel markers of colorectal tumors exhibiting microsatellite instability
By incorporating cell composition into their regression model, they identified 3,193 differentially expressed genes, of which 556 were deemed novel.
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Heart failure is associated with an increased risk of cancer
A study in more than 200,000 individuals has found that patients with heart failure are more likely to develop cancer compared to their peers without heart failure. The research is presented today at Heart Failure 2021, an online scientific congress of the European Society of Cardiology (ESC), and published in ESC Heart Failure, a journal of the ESC.
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Escape room simulation promotes infection control adherence at the temple VA
Designed initially for entertainment purposes, escape rooms are proving their value as medical training tools as demonstrated by the Central Texas Veterans Health Care System. Staff there have used the concept for a flu pandemic escape room and is reporting increased staff handwashing and acceptance of flu vaccines as a result.
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National Poll: 1 in 4 parents worry that their child is behind in developmental milestones
Nearly a quarter of parents have suspected their child might be delayed in their development, a new national poll finds - but they may not always share these concerns with a doctor.
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Saturated fatty acid levels increase when making memories
Saturated fatty acid levels unexpectedly rise in the brain during memory formation, according to University of Queensland researchers.
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USTC realizes the first on-chip valley-dependent quantum interference
USTC realized two-photon quantum interference in the structure of valley-dependent topological insulators based on the valley Hall effect.
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A novel method for controlling the microstructure and performance of 3D printed human implants
With the rapid development of biomedical technology, the replacement of human skeletal diseases through human implants has become an application market with high technical content and huge benefits. In order to quickly customize human implants with complex structures, Chinese scientists use 3D printing technology to prepare Ti-Mo alloy human implants, and then adjust the microstructure and performance of the human implants through subsequent heat treatment, so as to obtain human implant products with excellent compatibility.
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Researchers perform metabolomic profiling of individual enlarged lysosomes
The research team from Life Science and Medicine of University of Science and Technology of China, realized lysosome typing based on single lysosome metabonomic information for the first time by stablishing a single lysosome metabonomic mass spectrometry detection technology.
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Virome in marine ecosystems reveal remarkable invertebrate RNA virus diversity
Oceans viromes remain poorly understood and little is known about the ecological factors driving aquatic RNA virus evolution. In the study, reseaechers used a meta-transcriptomics approach to characterize the viromes of 58 marine invertebrates species across three seas, demonstrated the hidden diversity of marine invertebrates RNA viruses.
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Attomolar sensing: Fabrication of surface-enhanced raman scattering substrate
Surface-enhanced Raman scattering (SERS) permits multidisciplinary trace analyses and the potential detection of single molecules. Shi Bai and Koji Sugioka from RIKEN report a comprehensive review of recent progress in strategies for the fabrication of highly sensitive SERS substrates. Femtosecond laser-based techniques are discussed as a versatile tool for the fabrication of SERS substrates. Several approaches are highlighted for enhancing the performance of SERS sensing devices, and real-time sensing and biological applications are reviewed.
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Has the stilling of the surface wind speed ended in China?
The continuous weakening of global land surface wind speed (stilling) has seriously affected the ecological environment and social economy, especially restricted the sustainable development of the wind energy industry. A recent study systematically answered the question of whether the surface wind speed in China is still weakening.
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Multi-material multi-photon 3D laser micro- and nanoprinting
Most realized 3D architectures are composed of only a single polymeric material. Here, we review 3D printing of multi-materials on the nano- and microscale. We start with material properties that have been realized, using multi-photon photoresists. Next, we review manual and automated processes achieving dissimilar material properties in a single 3D structure by sequentially photo-exposing multiple photoresists and by controlled stimuli of a single photoresist. Instructive examples from biology, optics, mechanics, and electronics are discussed.
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Small p values may not yield robust findings: An example using REST-meta-PD
A large number of articles have been published using resting-state functional magnetic resonance imaging for clinical research, and almost all the results survived multiple comparisons correction, a standard procedure performed to reduce false positive rates. Now the researchers from more than 20 worldwide groups have found that in individual studies with small sample sizes, a smaller p value reduced true positive effect and did not save the reproducibility of true effects.
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Coral enhance its environmental adaptability by adjusting trophic status
Under the background of global warming and the increasing impact of human activities, the phenomenon of coral bleaching is becoming more and more serious. Scleractinian coral as mixotrophic organisms, but it is unclear about the impact of trophic flexibility on their environmental adaptability. Recent studies have revealed that coral could enhance its environmental adaptability by adjusting trophic status. This discovery was reported in the cover article of "SCIENCE CHINA: Earth Sciences", Issue 6, 2021.
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Researchers develop world-first weight loss device
University of Otago, New Zealand, and UK researchers have developed a world-first weight-loss device to help fight the global obesity epidemic.
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Study reveals over a £1 million in payments from pharma companies to APPGs
New research published in PLOS One suggests there is a significant lack of transparency in corporate funding to APPGs
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AI learns to predict human behavior from videos
New Columbia Engineering study unveils a computer vision technique for giving machines a more intuitive sense for what will happen next by leveraging higher-level associations between people, animals, and objects."Our algorithm is a step toward machines being able to make better predictions about human behavior, and thus better coordinate their actions with ours," said Computer Science Professor Carl Vondrick. "Our results open a number of possibilities for human-robot collaboration, autonomous vehicles, and assistive technology."
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