The blood-brain barrier prevents xenobiotics from entering the central nervous system. Growing evidence indicates that neurotoxins, such as tributyltin, manganese and nanoparticles, may disrupt the function of the blood-brain and blood-cerebrospinal fluid (CSF) barriers. Previous studies show that chronic acrylamide exposure leads to central and peripheral neuropathy. However, very few studies have focused on the effects of acrylamide exposure on these barriers. Prof. Yanshu Zhang and co-workers from Hebei United University in China found that acrylamide exposure damages the blood-cerebrospinal fluid barrier and impairs secretory and transport functions. These changes may underlie acrylamide-induced neurotoxicity. The research achievements have been published in the Neural Regeneration Research.
Source: Neural Regeneration Research