The incidence and mortality of tumor keep ascending all over the world. Gecko had definite effect on malignant tumor in clinical practices reports. However, there was no study on the pharmacological studies of Gecko and its mechanisms of anti-tumor action remained unclear.
A research team led by Prof. Wang from Henan University of China addressed this question, and their findings were published on 7 July 2008, in the World Journal of Gastroenterology.
As we know, the effect on anti-tumor of traditional Chinese medicine (TCM) is related to more pathways and more targets. Most studies on action mechanisms of TCM in anti-tumor showed that TCM could inhibit tumors though supporting the healthy energy and strengthening the body resistance. The article showed that Gecko could not only reinforce immunity of organism but also induction of tumor cell apoptosis and the down-regulation of protein expression of VEGF and bFGF.
Chemotherapy, one of the major methods to treat cancer in Western medicine at present, has a poor selectivity and strong toxic and side effects, thus influencing its anticancer effect. In the past 40 years, Chinese experts have gained remarkable achievements in cancer treatment by integrating TCM with chemotherapy. This article gives us pharmacological studies of Gecko about antitumor and thus may provide foundation for its effective constituent.