HONOLULU – October 29, 2009 – Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, announced today that it will present key scientific data on its Attention-Deficit/Hyperactivity Disorder (ADHD) treatments, INTUNIV™ (guanfacine) Extended Release Tablets, Vyvanse® (lisdexamfetamine dimesylate) Capsules CII, and Daytrana® (methylphenidate transdermal system) CII, at a national meeting of psychiatrists to be held October 27 - November 1 in Honolulu.

"Shire is committed to the advancement of ADHD treatment research and is leading the way in developing a diverse range of safe and effective ADHD treatments," said Michael Yasick, Senior Vice President of the Shire ADHD Business Unit. "We are excited to provide new scientific data on our ADHD portfolio, which includes the newest FDA-approved ADHD treatment INTUNIV; Vyvanse, the first prodrug stimulant for the treatment of ADHD; and Daytrana, the only patch approved for the treatment of ADHD. We are proud to provide important contributions to the growing body of research on our ADHD portfolio to the medical community."

Following is a summary of the key Shire scientific presentations. Information about these data presentations mentioned in this media alert is embargoed until the respective presentation sessions have taken place at the meeting.

INTUNIV (guanfacine) Extended Release Tablets

October 29, 2009; 6:30 PM to 9:00 PM ET / 12:30 PM to 3:00 PM HT Effects of Guanfacine Extended Release in Children Aged 6 to 12 With Oppositional Symptoms and a Diagnosis of ADHD Poster Presentation # 3.8

October 29, 2009; 6:30 PM to 9:00 PM ET / 12:30 PM to 3:00 PM HT Twenty-Four–Month Effectiveness of Guanfacine Extended Release in Children and Adolescents Aged 6 to 17 Years With ADHD Poster Presentation # 3.24

Vyvanse (lisdexamfetamine dimesylate) Capsules CII

October 29, 2009; 6:30 PM to 9:00 PM ET / 12:30 PM to 3:00 PM HT The Effects of Lisdexamfetamine Dimesylate on Emotional Lability in Children 6 to 12 Years of Age With ADHD in a Double-Blind, Placebo-Controlled Trial Poster Presentation # 3.6

October 29, 2009; 6:30 PM to 9:00 PM ET / 12:30 PM to 3:00 PM HT Reading Performance as a Function of Treatment With Lisdexamfetamine Dimesylate in Elementary School Children Diagnosed With ADHD Poster Presentation # 3.19

October 29, 2009; 6:30 PM to 9:00 PM ET / 12:30 PM to 3:00 PM HT Clinical Response and Symptomatic Remission in Children Treated With Lisdexamfetamine Dimesylate for ADHD Poster Presentation # 3.20

October 29, 2009; 6:30 PM to 9:00 PM ET / 12:30 PM to 3:00 PM HT Cardiovascular Outcomes in Children and Adults Treated With Lisdexamfetamine Dimesylate for ADHD Poster Presentation # 3.23

Daytrana (methylphenidate transdermal system) CII

October 30, 2009; 3:00 PM to 5:30 PM ET / 9:00 AM to 11:30 AM HT Pharmacokinetics of Methylphenidate Transdermal System and Osmotic-Release Oral System Methylphenidate in Children and Adolescents With ADHD Poster Presentation # 4.52

October 30, 2009; 3:00 PM to 5:30 PM ET / 9:00 AM to 11:30 AM HT Pharmacokinetic Predictors of Abuse-Related Liking With Transdermal and Subcutaneous Methylphenidate Poster Presentation # 4.54

October 30, 2009; 3:00 PM to 5:30 PM ET / 9:00 AM to 11:30 AM HT Evaluation of the Tolerability and Effectiveness of the Methylphenidate Transdermal System Over 6 Months in Adolescents With ADHD Poster Presentation # 4.55