Researchers identify immune cells that contribute to the development of multiple sclerosis

Posted By News On December 29, 2012 - 11:13pm

Multiple sclerosis (MS) is characterized by the infiltration of the central nervous system (CNS) by immune cells.

A particular type of immune cell, Tc17, has been found in MS lesions in humans, but it is unclear what role these cells play in disease pathogenesis. In the Journal of Clinical Investigation, researchers led by Magdalena Huber at the University of Marburg in Germany used a mouse model of MS to determine the role of Tc17 cells.

They found that Tc17 cells help Th17 immune cells to invade the CNS by secreting the protein IL-17. Without Tc17 cells, the Th17 cells did not accumulate in the CNS, preventing the development of MS.

This study demonstrates that Tc17 cells help initiate MS by allowing immune cells to reach the CNS and suggests that therapies targeting Tc17 cells might be helpful in treating early MS.

TITLE: IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

My name is moises reyes im from guadalajara mexico my wife has ms and curently we are using the copaxone tratment ( GLATIRAMIER OF ACETATO ) This medicine has keept my wife a little under control . Also she is using the amino acid called BR fix which has been recomended for a friend just to try emproving the symptoms of ms on my wife. I dont know if it will help us but we dont have any more to lose. We are using both . And i wondeeing if this amino acid iss related wit h all mentioned on this article and what can we do to get avoid the th17 acumulate on cns regards Moises Reyes

Hello, please consider getting your wife on stronger meds quickly. Avonex, Copaxone, and BetaSeron are only < 25% effective on average.

Try a combo therapy (rituxan/copaxone) or maybe Tysabri or something that gets higher efficacy (> 90% is what you're striving for).

Also consider cutting gluten from her diet entirely.

my wife was on Avonex, then Copaxone for >20 years, and just passed this year in Feb - she was 46.

we got her into the Barrow Neuro too late. Also check out the Myelin Repair Foundation, they are getting ready to release a therapy to regenerate lost myelin.

I Wish you and your wife all the best.
John, AZ, USA

My name is moises reyes im from guadalajara mexico my wife has ms and curently we are using the copaxone tratment ( GLATIRAMIER OF ACETATO ) This medicine has keept my wife a little under control . Also she is using the amino acid called BR fix which has been recomended for a friend just to try emproving the symptoms of ms on my wife. I dont know if it will help us but we dont have any more to lose. We are using both . And i wondeeing if this amino acid iss related wit h all mentioned on this article and what can we do to get avoid the th17 acumulate on cns regards Moises Reyes

Google CCSVI

Moises- I do hope your wife feels better. Any study that finds a clue - is a good one! I am so thankful for these wonderful scientists and have faith in their work. I have had MS for almost 10 years. I was put on Copaxone the day of my diagnoses and have been on it ever since. Everyone is so different in their course of the disease. I have found regular exercise is my best treatment along with the copaxone. I try to swim 5-6 days a week, as this exercise keeps my body core temperature down while alowing me to have a very productive workout. Exercise has been proven to help with stress levels and disease progression. I also take N acetylglucosamine, Vitamin D and Saffron tea. I buy Iranian style and make a tea out of a few threads. The crocin in saffron is suppose to have neuroprotective agents, but none of those have been proven to help yet. I currently an in R/R stage and have only sensory problems. ( A little tingling and burning from my last relapse 2 1/2 years ago.) I wish your wife and you the best and will keep you in my prayers. :)

I have been taking an oral medicine called LDN (Low Dose Naltrexone) for close to 2 years now, and it has helped me and my MS. Google LDN, and one will find a lot of information on it, and how it helps MSers, and other with auto-immune diseases. I also take a number of supplements, the most important ones being Vitamin D3, sublingual B12, and Magnesium Glycinate.
Good luck to your wife, Moises. :)

In view of the fact that a growing number of people previously diagnosed with MS really do not have MS but Lyme Disease or Cpn or mercury Toxicity, it would behoove these scientists to first rule out these possibilities by doing the appropriate testing for these problems in real patients. Until they do, this is just another hair-brained hypothesis being tried out on mice which do not normally get MS.

Just a wild guess, but this latest insanity from the scientific community is being paid for by Big Pharma, right?? And we are supposed to be grateful, right? NOT!! They have already killed off enough peddling their autoimmune theory (that is ALL it is - a theory) and their useless drugs that are supposed to slow down relapses - something they are incapable of predicting. Without any drugs at all, some people go for decades between relapses. Two and a half years on Copaxone does not seem very impressive at all. A little good, old fashioned logic would be a nice change!

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