Marijuana use may increase risk of testicular cancer

Posted By News On September 10, 2012 - 4:30am

A new study from the University of Southern California (USC) has found a link between recreational marijuana use and an increased risk of developing subtypes of testicular cancer that tend to carry a somewhat worse prognosis. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest that the potential cancer-causing effects of marijuana on testicular cells should be considered not only in personal decisions regarding recreational drug use, but also when marijuana and its derivatives are used for therapeutic purposes in young male patients.

Testicular cancer is the most common cancer diagnosed in young men ages 15 to 45 years. The malignancy is becoming more common, and researchers suspect this is due to increasing exposure to unrecognized environmental causes.

To see if recreational drug use might play a role, Victoria Cortessis, MSPH, PhD, assistant professor of preventive medicine at the Keck School of Medicine of USC in Los Angeles, and her colleagues looked at the self-reported history of recreational drug use in 163 young men diagnosed with testicular cancer and compared it with that of 292 healthy men of the same age and race/ethnicity.

The investigators found that men with a history of using marijuana were twice as likely to have subtypes of testicular cancer called non-seminoma and mixed germ cell tumors. These tumors usually occur in younger men and carry a somewhat worse prognosis than the seminoma subtype. The study's findings confirm those from two previous reports in CANCER on a potential link between marijuana use and testicular cancer.

"We do not know what marijuana triggers in the testis that may lead to carcinogenesis, although we speculate that it may be acting through the endocannabinoid system—the cellular network that responds to the active ingredient in marijuana—since this system has been shown to be important in the formation of sperm," said Cortessis.

The researchers also discovered that men with a history of using cocaine had a reduced risk of both subtypes of testicular cancer. This finding suggests that men with testicular cancer are not simply more willing to report a history of using recreational drugs. While it is unknown how cocaine may influence testicular cancer risk, the authors suspect that the drug may kill sperm-producing germ cells since it has this effect on experimental animals.

"If this is correct, then 'prevention' would come at a high price," Cortessis said. "Although germ cells can not develop cancer if they are first destroyed, fertility would also be impaired. Since this is the first study in which an association between cocaine use and lower testis cancer risk is noted, additional epidemiological studies are needed to validate the results."

Source: Wiley

oh my god another article that bases it's information off of a failed cancer study. i'm glad to see the PHD professors are using their time wisely when a 15 year old is inventing the best plausible and cheapest pancreatic cancer testing. the only thing realistic about this article (which they don't state) is people who smoke on average will eat worse foods, most likely leading to "testi cancer". stop relating cancer to weed when it is known weed fights cancer spread

this guys right i smoke weed everyday and my balls are fine.

Remarkable!~After having used Cannabis fir Forty years, BOTH the fella's have never been better. I do realize our "fearless (soulless and and brainless) leaders' are cranking up the propaganda machine.
Bottom line-this "new groundbreaking study" is FALSE!~- Having researched Cannabis since 1981, I have personally seen no-such outcome.
It is truly reprehensible, the lengths to which prohibitionists and government will go-to obfuscate reality, and continually feed the weak-minded and uneducated.
God help us..Especially if you believe the "official" line. It's a LINE all right.

Goodness, Gracious, Great Balls of Fire