Neurotensin conjugate provides pain relief in animal models
The small peptide neurotensin is a potent regulator of dopamine signaling and can provide dramatic pain relief; however, the blood brain barrier provides a substantial challenge toward clinical use of neurotensin for analgesia. In this issue of the Journal of Clinical Investigation, Philippe Sarret and colleagues at Université de Sherbrooke generated a conjugate of neurotensin with a peptide able to cross the blood brain barrier and evaluated the analgesic effects of this molecule in animal models of pain. The authors observed efficient transportation of the conjugate (ANG2002) across the blood brain barrier and dose-dependent pain relief in multiple models. The results from this study suggest that ANG2002 has potential to be effective for clinical pain management.
TITLE: Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties
AUTHOR CONTACT: Philippe Sarret Université de Sherbrooke, Sherbrooke, PQ, CAN Phone: 819-820-6868 #12554; Fax: 819-820-6887; E-mail: philippe.sarret@usherbrooke.ca
View this article at: http://www.jci.org/articles/view/70647?key=d7ec1ecdc3b327ae271a
T cell repertoire following hematopoietic stem cell transplant
A promising treatment for hematologic and other malignancies is the transplantation of hematopoietic stem cells isolated from the patient. The use of an individuals own stem cells reduces complications involved with graft rejection;however, many patients develop autoimmune disease or other complications following the procedure. In this issue of the Journal of Clinical Investigation, Laurence Turka and colleagues from Massachusetts General Hospital evaluated the T cell response in a cohort of poor-prognosis MS patients following hematopoietic stem cell transplantation (HSCT) and determined that HSCT had differential effects on T cell repertoire. Importantly, patients with a diverse T cell population following the procedure were more likely to respond well to treatment.
TITLE: T cell repertoire renewal following autologous stem cell transplantation for multiple sclerosis
AUTHOR CONTACT: Laurence A. Turka Massachusetts General Hospital, Boston, MA, USA Phone: 617 724-7711; Fax: ; E-mail: lturka@partners.org
View this article at: http://www.jci.org/articles/view/71691?key=b64763243f594bab6646
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TITLE: Serotonergic mechanisms responsible for levodopa-induced dyskinesias in Parkinson's disease patients
AUTHOR CONTACT: Marios Politis Imperial College London, London, , GBR Phone: +4402083833754; E-mail: marios.politis@imperial.ac.uk
View this article at: http://www.jci.org/articles/view/71640?key=53290de4e3538ea486e7
TITLE: Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk
AUTHOR CONTACT: Philippe Lefebvre INSERM, LILLE, , FRA Phone: +33.3209774220; E-mail: philippe-claude.lefebvre@inserm.fr
View this article at: http://www.jci.org/articles/view/68815?key=b6447701e370aab5dcf0
TITLE: Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance
AUTHOR CONTACT: Shuta Ishibe Yale University School of Medicine, New Haven, CT, USA Phone: 203-737-4170; Fax: 203-785-4904; E-mail: shuta.ishibe@yale.edu
View this article at: http://www.jci.org/articles/view/69778?key=b2362d17c39fcc7d7ef2
TITLE: Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
AUTHOR CONTACT: Nicholas Leeper Stanford University School of Medicine, Stanford, CA, USA Phone: 415-794-7712; E-mail: nleeper@stanford.edu
View this article at: http://www.jci.org/articles/view/70391?key=7731007a399ee021075e
TITLE: Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome
AUTHOR CONTACT: Francesco Ramirez Mount Sinai School of Medicine, New York, NY, USA Phone: 212-241-7237; Fax: 212-996-7214; E-mail: francesco.ramirez@mssm.edu
View this article at: http://www.jci.org/articles/view/71059?key=10982d70689da49c44ac
TITLE: Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis
AUTHOR CONTACT: Jeffrey Schelling Case Western Reserve University, Cleveland, OH, USA Phone: (216)778-3079; Fax: (216)778-4321; E-mail: :Jeffrey.schelling@case.edu
View this article at: http://www.jci.org/articles/view/71863?key=0ce2eb6cd213e7f0230e
TITLE: Bitter and sweet taste receptors regulate human upper respiratory innate immunity
AUTHOR CONTACT: Noam Cohen Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Phone: 215-823-5800 ext 3892; Fax: 215-349-5977; E-mail: cohenn@uphs.upenn.edu
View this article at: http://www.jci.org/articles/view/72094?key=80384aee45c4752a4dd2
TITLE: Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion
AUTHOR CONTACT: Ru-Rong Ji Duke University Medical Center, Durham, NC, USA Phone: 919-684-9687; E-mail: u-rong.ji@duke.edu
View this article at: http://www.jci.org/articles/view/72230?key=e5732c9ba6685986b16a