Gut bacteria linked to autism-related behavior in mice

Posted By News On December 5, 2013 - 5:31pm

Mice whose mothers suffered from infection or inflammation during pregnancy are at greater risk for developing behaviors similar to those seen in people with autism spectrum disorders (ASD). Now, researchers reporting in the Cell Press journal Cell on December 5 have linked those neurodevelopmental symptoms in the mice to changes in the bacteria living in the animals' guts. What's more, when researchers treated those animals with bacteria found in the healthy gut, a number of behavioral abnormalities including anxiety-like behavior largely went away.

"Several studies have shown that the microbiota can influence a variety of behaviors, from anxiety and pain to social and emotional behavior," said Elaine Hsiao from the California Institute of Technology. "Our work is the first to demonstrate that modulating the microbiota can influence autism-related behaviors in the context of a disease model."

Although the researchers urge caution, the findings link at least some symptoms of ASD to the gut and suggest that probiotics might have a therapeutic role in such cases. They say clinical trials are now needed to gather the evidence to verify this link found in mice.

Hsiao, along with Paul Patterson, Sarkis Mazmanian, and their colleagues, knew that some individuals with ASD also suffer from gastrointestinal symptoms. To investigate the connection, they looked to the maternal immune activation (MIA) mouse model, which has previously been used to model several neurodevelopmental disorders, including autism. What they uncovered in offspring of MIA animals with autism-like symptoms were gastrointestinal abnormalities and changes in the gut microbial community.

When the mice were given oral doses of the human gut microbe Bacteroides fragilis, their gastrointestinal and behavioral abnormalities were relieved. Further work showed that MIA mice have altered blood levels of some metabolites, many of which are modulated by B. fragilis. When otherwise normal mice were treated with a metabolite found at elevated levels in MIA animals, they too showed certain behavioral abnormalities, suggesting a direct link between gut bacteria, metabolites, and behavior.

"Taken together," the researchers concluded, "these findings support a gut-microbiome-brain connection in a mouse model of neurodevelopmental disorders and identify a potential probiotic therapy for gastrointestinal and behavioral symptoms in human disorders, including autism."

Source: Cell Press

What is happening is an epidemic!!! Dr.'s are giving children antibiotics and destroying their guts!! Then they are giving them immunizations and the already destroyed immune systems get overwhelmed and child after child is being diagnosed with Autism... When in reality they are being damaged!!! If you read the inserts for the immunizations from the manufacturers it tells you not to give to a child that has been ill. Doctors are ignoring this warning and giving children loads of antibiotics, then loading them with virus's from the shots!! I am looking for someone to help me get my grandbaby fixed! I want a doctor that will monitor her for her leaky gut, (would like to try replacing the bacteria with a fecal transplant) we need to fix her gut... she is overwhelmed with yeast also from the antibiotics!! Parents you need to know what is going on!! we are loosing a generation!! The doctors of today are telling parents its normal to have a shot and then have a seizure, temps of 104 degrees is fine and so many parents are believing that they have a truely autistic child when in fact the doctors are damaging them!!

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