Cyclin D1b is a protein that is induced during cancer progression; however, it's exact function in cancer is poorly understood.
Researchers led by Karen Knudsen at Thomas Jefferson University's Kimmel Cancer Center examined the role of cyclin D1b in prostate cancer.
Using a mouse model of the disease, they found that cyclin D1b promoted the expression of genes that allow the cancer to grow and metastasize. Additionally, Knudsen and colleagues demonstrated that cyclin D1b's effects were dependent on androgen receptor signaling.
These findings identify cyclin D1b as an important regulator of prostate cancer progression and suggest that this pathway is a potential therapeutic target in the treatment of prostate cancer.
TITLE: Convergence of oncogenic and hormone receptor pathways promotes pro-metastatic phenotypes
Journal of Clinical Investigation