Breast cancer cells interact with non-cancerous tissue to drive metastasis

Posted By News On December 26, 2012 - 9:30pm

In addition to mutations, environmental conditions created by the tissues surrounding tumors (stroma) play a major role in cancer progression. Researchers led by Gregg Semenza at Johns Hopkins University examined the interactions between breast cancer cells and the stroma to identify underlying pro-metastatic molecular mechanisms.

They found that both breast cancer cells and the stroma secrete proteins that influence the behavior of each cell type.

Additionally, Semenza and colleagues found that a group of proteins known as HIFs were required for stroma-driven metastases, suggesting that drugs which inhibit this class of proteins may be useful in preventing breast cancer metastasis.

TITLE: Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis

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