DALLAS June 12, 2008 - UT Southwestern Medical Center psychiatry researchers have taken what they learned from their groundbreaking research on treating depression and are applying it to real-world clinical settings.
The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study was the largest ever on the treatment of major depressive disorder and is considered a benchmark in the field of depression research. The six-year, $33 million study initially included more than 4,000 patients from clinics across the country.
EDITOR'S PICK: New target to enhance anticancer drug sensitivity found in translation
The development of resistance to anticancer chemotherapeutic agents remains a large problem. In some cases, such resistance is associated with altered control of a cellular process known as translation, which is central to the generation of proteins. New data, generated by Jerry Pelletier and colleagues, at McGill University, Montreal, have identified a drug that can enhance the sensitivity of mouse cancer cells to standard anticancer chemotherapeutic agents.
LOS ALAMOS, New Mexico, June 12, 2008—Less than a week after Los Alamos National Laboratory's Roadrunner supercomputer began operating at world-record petaflop/s data-processing speeds, Los Alamos researchers are already using the computer to mimic extremely complex neurological processes.
Welcome to the new frontier of research at Los Alamos: science at the petascale.
New evidence shows that the brains of adults with autism are "wired" differently from people without the disorder, and this abnormal pattern of connectivity may be responsible for the social impairments that are characteristic of autism.
Using functional magnetic resonance imaging, a team of researchers affiliated with the University of Washington's Autism Center also found that the most severely socially impaired subjects in the study exhibited the most abnormal pattern of connectivity among a network of brain regions involved in face processing.
After a stroke, even unaffected areas of the brain are at risk depolarization waves arise at the edges of the dead tissue and spread through the adjacent areas of the brain. If these waves are repeated, more cells die. This has previously been observed only in animal studies.
PROVIDENCE, R.I. Teens who repeatedly cut themselves are more likely to engage in risky sexual behavior, increasing their chances of possibly contracting HIV, according to a study in the June issue of the Journal of Developmental and Behavioral Pediatrics.
The proteins upon which life depends share an attribute with paper airplanes: Unless folded properly, they just won't fly.
But researchers have been puzzled by how the long, linear proteins cranked out by the ribosome factories in a cell are folded into the shapes they must assume to perform their function. They only have known that for many of the most complex and essential proteins, the folding takes place out of sight, hidden in the inner cavity of a type of molecule called a chaperonin.
ST. PAUL, Minn. Mexican Americans and women may be at higher risk for subarachnoid hemorrhage, a type of stroke involving bleeding in the space around the brain, according to a study published in the June 11, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology.