Body

Toronto, ON, Canada – Diabetes mellitus is a metabolic disorder characterized by altered glucose tolerance and impairedlipid and carbohydrate metabolism, and is associated with a number of complications directly resulting from hyperglycemiainducedinflammation. Vascular changes in diabetes lead to increased risk of myocardial infarction and stroke due to atherosclerosis,retinopathy, end-stage renal disease, debilitating neuropathies, poor wound healing, enhanced risk of infection, andperiodontal disease.

Toronto, ON, Canada – Dental caries, or tooth decay, continues to be the most prevalent infectious disease in the world,presenting significant public health challenges and socio-economic consequences. It leads to the loss of the hard tissues ofthe tooth, followed by inflammation and necrosis of the subjacent dental pulp. In the U.S. alone, over 20 million dental restorationsare placed each year, with failure rates of up to 60%. Hence, there exists a critical need for better biologic therapeuticsto restore the damaged dentin-pulp complex to its original form and function.

MISSION VIEJO, Calif. (Aug. 24, 2017) - Consuming one fresh avocado per day may lead to improved cognitive function in healthy older adults due to increased lutein levels in the brain and eye, according to new research published in the journal Nutrients. The research tracked how 40 healthy adults ages 50 and over who ate one fresh avocado a day for six months experienced a 25% increase in lutein levels in their eyes and significantly improved working memory and problem-solving skills.

Removing a single gene from the brains of mice and zebrafish causes these animals to become more anxious than normal. Researchers from University of Utah Health show that eliminating the gene encoding Lef1 disrupts the development of certain nerve cells in the hypothalamus that affect stress and anxiety. These results are the first implication that Lef1 functions in the hypothalamus to mediate behavior, knowledge that could prove useful for diagnosing and treating human brain disorders.

One in four patients in a university hospital suffers from diabetes (22 percent), and again as many suffer from prediabetes (24 percent). These were the findings of a current study by researchers in Tübingen of the German Center for Diabetes Research (DZD) and Helmholtz Zentrum München. Further results of the study: Patients with diabetes have prolonged hospital stays and a higher risk of complications.

In mice that are given a high-fat diet, an increased production of the enzyme DPP4* by the liver promotes an increase in body fat, the development of fatty liver disease and insulin resistance. These were the findings of a current study by DZD-researchers in Potsdam and Tübingen.

DALLAS - Aug. 24, 2017 - Scientists from the Children's Medical Center Research Institute at UT Southwestern (CRI) have developed an innovative system to identify and characterize the molecular components that control the activities of regulatory DNA sequences in the human genome.

DALLAS - August 23, 2017 - UT Southwestern Medical Center researchers report for the first time that tumors stressed by cancer immunotherapy release their mitochondrial DNA into nearby immune cells, triggering a host alert system.

Bottom Line: Scientists have found distinctive portions of genetic material--known as lncRNAs--that help sperm develop. Male mice lacking a particular lncRNA have low sperm count, suggesting lncRNAs could represent novel infertility drug targets.

Journal in Which the Study was Published: Biology of Reproduction

PHILADELPHIA -- The "involuntary treatment" of unwilling psychiatric patients has long been accepted as necessary in some cases, for the sake of patients and society, though it can raise serious ethical concerns as well as legal barriers.