Protein misprediction uncovered by new technique

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A new bioinformatics tool is capable of identifying and correcting abnormal, incomplete and mispredicted protein annotations in public databases. The MisPred tool, described today in the open access journal BMC Bioinformatics, currently uses five principles to identify suspect proteins that are likely to be abnormal or mispredicted.

Olive leaf extract can help tackle high blood pressure and cholesterol

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Taking 1000mg of a specific olive leaf extract (EFLA®943) can lower cholesterol and lower blood pressure in patients with mild hypertension (high blood pressure). These findings came from a 'Twins' trial, in which different treatments were given to identical twins. By doing this, researchers could increase the power of their data by eliminating some of the uncertainties caused by genetic variations between individual people.

The research is published in the latest edition of Phytotherapy Research.

Global survey highlights need for cancer prevention campaigns to correct misbeliefs

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GENEVA, Switzerland – Many people hold mistaken beliefs about what causes cancer, tending to inflate the threat from environmental factors that have relatively little impact while minimizing the hazards of behaviours well established as cancer risk factors, according to the first global survey on the topic.

The survey, conducted by Roy Morgan Research and Gallup International on behalf of the International Union of Against Cancer (UICC), identified key areas where misconceptions could be addressed and where lives could be saved.

Researchers find high levels of toxic metals in herbal medicine products sold online

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Boston, MA--Researchers at Boston University School of Medicine (BUSM) have found that one fifth of both U.S.-manufactured and Indian-manufactured Ayurvedic medicines purchased via the Internet contain lead, mercury or arsenic. These findings appear in the August 27th issue of the Journal of the American Medical Association (JAMA).

Also in the Aug. 26 JNCI

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Novel Trial Design Aims to Speed Drug Development

Researchers propose a novel multi-arm trial design that can test several therapies simultaneously and could speed drug development in cancer.

Scientists have gained important insights into the biological underpinnings of cancer, but this knowledge has not led to a jump in the number of therapies approved for clinical use. One possible reason for the slower than expected progress is the time required for clinical testing with current trial designs.

Consumption of nuts, corn or popcorn not associated with increased risk of diverticulosis in men

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Contrary to a common recommendation to avoid eating popcorn, nuts and corn to prevent diverticular complications, a large prospective study of men indicates that the consumption of these foods does not increase the risk of diverticulosis or diverticular complications, according to a study in the August 27 issue of JAMA.

Angiotensin inhibitors and receptor blockers linked to lower risk of nonmelanoma skin cancer

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The use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) was associated with a reduced risk of basal cell or squamous cell skin cancers in U.S. veterans, researchers report in the August 26 online issue of the Journal of the National Cancer Institute.

History of nonmelanoma skin cancer is associated with increased risk for subsequent malignancies

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Individuals with a history of nonmelanoma skin cancer (NMSC) are at increased risk for other cancers, according to a study published in the August 26 online issue of the Journal of the National Cancer Institute.

Previous studies have documented that people who have had nonmelanoma skin cancer were at increased risk for developing melanoma, but it is less well-established whether they were also at risk for cancers that do not involve the skin.

Findings challenge common practice regarding glucose control for critically ill patients

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An analysis of randomized trials indicates that for critically ill adults, tight glucose control is not associated with a significantly reduced risk of death in the hospital, but is associated with an increased risk of hypoglycemia, calling into question the recommendation by many professional societies for tight glucose control for these patients, according to an article in the August 27 issue of JAMA.

High levels of uric acid may be associated with high blood pressure

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Reducing levels of uric acid in blood lowered blood pressure to normal in most teens in a study designed to investigate a possible link between blood pressure and the chemical, a waste product of the body's normal metabolism, said researchers at Baylor College of Medicine in a report that appears in the current issue of the Journal of the American Medical Association.