Gummy bears that fight plaque

Tweet

The tooth-protecting sugar substitute xylitol has been incorporated into gummy bears to produce a sweet snack that may prevent dental problems. Research published today in the open access journal BMC Oral Health describes how giving children four of the xylitol bears three times a day during school hours results in a decrease in the plaque bacteria that cause tooth decay.

Giving an additional early vaccination may reduce measles outbreaks

Tweet

Outbreaks of measles in developing countries may be reduced by vaccinating infants at 4.5 months of age as well as at the World Health Organization's recommended routine vaccination at 9 months, according to a study published on BMJ.com today.

These findings should lead to reconsideration of the policy for vaccination during measles outbreaks and in humanitarian emergencies, say the authors.

Consortium develops new method enabling routine targeted gene modification

Tweet

A multi-institutional team led by Massachusetts General Hospital (MGH) investigators has developed a powerful new tool for genomic research and medicine – a robust method for generating synthetic enzymes that can target particular DNA sequences for inactivation or repair. In the July 25 issue of Molecular Cell, the researchers describe an efficient, publicly available method to engineer customized zinc-finger nucleases (ZFNs), which can be used to induce specific genomic modifications in many types of cells.

Older people may need less sleep, study finds

Tweet

Along with all the other changes that come with age, healthy older people also lose some capacity for sleep, according to a new report published online on July 24th in Current Biology, a Cell Press publication. When asked to stay in bed for 16 hours in the dark each day for several days, younger people get an average of 9 hours of shuteye compared to 7.5 for older people, the researchers report.

Prevailing theory of aging challenged in Stanford worm study

Tweet

STANFORD, Calif. - Age may not be rust after all. Specific genetic instructions drive aging in worms, report researchers at the Stanford University School of Medicine. Their discovery contradicts the prevailing theory that aging is a buildup of tissue damage akin to rust, and implies science might eventually halt or even reverse the ravages of age.

"We were really surprised," said Stuart Kim, PhD, professor of developmental biology and of genetics, who is the senior author of the research.

A new cellular pathway linked to cancer is identified by NYU researchers

Tweet

NEW YORK, July 24, 2008 – In the life of a cell, the response to DNA damage determines whether the cell is fated to pause and repair itself, commit suicide, or grow uncontrollably, a route leading to cancer. In a new study, published in the July 25th issue of Cell, scientists at NYU Langone Medical Center have identified a way that cells respond to DNA damage through a process that targets proteins for disposal. The finding points to a new pathway for the development of cancer and suggests a new way of sensitizing cancer cells to treatment.

New study of gene evolution could lead to better understanding of neurodegenerative disease

Tweet

AUSTIN, Texas—Genetic evolution is strongly shaped by genes' efforts to prevent or tolerate errors in the production of proteins, scientists at The University of Texas at Austin and Harvard University have found.

Their study also suggests that the cost of errors in protein production may lie in the malformed proteins themselves, rather than in the loss of functional proteins. Misfolded proteins can build up in long-lived cells, like neurons, and cause neurodegenerative diseases.

Researchers unravel key mechanism of cellular damage in aging and disease

Tweet

Researchers have taken a first snapshot of how a class of highly reactive molecules inflicts cellular damage as part of aging, heart disease, stroke, cancer, diabetes, kidney disease and Alzheimer's disease to name a few. According to a study published today in the journal Cell, researchers have discovered a tool that can monitor related damage and determine the degree to which antioxidant drugs effectively combat disease.

Circadian rhythm-metabolism link discovered

Tweet

Irvine, Calif. — UC Irvine researchers have found a molecular link between circadian rhythms – our own body clock – and metabolism. The discovery reveals new possibilities for the treatment of diabetes, obesity and other related diseases.

Paolo Sassone-Corsi, Distinguished Professor and Chair of Pharmacology, and his colleagues have identified that an essential protein called CLOCK that regulates the body's circadian rhythms, works in balance with another protein called SIRT1 that modulates how much energy a cell uses.

Various species' genes evolve to minimize protein production errors

Tweet

CAMBRIDGE, Mass. -- Scientists at Harvard University and the University of Texas at Austin have found that genetic evolution is strongly shaped by genes' efforts to prevent or tolerate errors in protein production.

Their study also suggests that the cost of errors in protein production may lie in the malformed proteins themselves, rather than the loss of functional proteins. Misfolded proteins can build up in long-lived cells, like neurons, and cause neurodegenerative diseases.