NIH creates Atlas of Human Malformation Syndromes in Diverse Populations

NIH creates Atlas of Human Malformation Syndromes in Diverse Populations

Researchers with the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, have collaborated with physicians and medical geneticists around the world to create the Atlas of Human Malformation Syndromes in Diverse Populations. Health care providers can use the new atlas to diagnose diverse patients with inherited diseases by comparing physical traits (called phenotypes) and written descriptions of their symptoms with photos and descriptions of people with the same condition and ancestry.

In older adults, frailty and depression symptoms are linked and can affect spouses

In older adults, frailty and depression symptoms are linked and can affect spouses

Frailty, a condition that affects 10 percent of people aged 65 and older, can make older adults more prone to disability, falls, hospitalization and a shorter lifespan. Recently, researchers writing in the Journal of the American Geriatrics Society examined the effects of frailty and depression on married couples. Although we know much about the effects of frailty and depression on individuals, up until now, little has been uncovered about how these two conditions may be connected within couples.

CNIC researchers identify a new signaling mechanism implicated in congenital aortic valve disease

CNIC researchers identify a new signaling mechanism implicated in congenital aortic valve disease

Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have demonstrated the crucial role of the NOTCH signaling pathway in the development of a fundamental heart structure, the heart valves. These valves ensure unidirectional bloodflow with each heartbeat, and open and close millions of times during a person's lifetime.

Lower weight, diabetes, and heart disease can worsen quality of life for frail older women

Lower weight, diabetes, and heart disease can worsen quality of life for frail older women

Researchers writing in the Journal of the American Geriatrics Society recently learned that older women who are frail, and who have six or more chronic health conditions, are twice as likely to have a lower quality of life compared to women with less than three risk factors.

Mechanism discovered for plants to regulate their flowering in a warming world

Mechanism discovered for plants to regulate their flowering in a warming world

Monash researchers have discovered a new mechanism that enables plants to regulate their flowering in response to raised temperatures.

Published today in the journal Nature Plants, the finding could potentially lead to the development of technology allowing us to control the physiological response of plants and mitigate the impacts of warming temperatures.

The Monash team led by Associate Professor Sureshkumar Balasubramanian made the discovery by applying a combination of genetic, molecular and computational biology experiments to the flowering plant Arabidopsis.

Why can't a woman play tennis like a man?

BEER-SHEVA...April 29, 2016 -- Changing court conditions to address differences in men's and women's play might make women's tennis matches more competitive, according to a new study by Ben-Gurion University of the Negev (BGU) and other Israeli researchers.

Many sports adapt rules and equipment to better meet the needs of female competitors. For example, the net is lower in women's volleyball; basketballs are smaller; javelins are lighter; and hurdles are lower.

Cancer drug may treat sepsis, other uncontrollable immune responses to infection

WHAT:

HPV infection can be identified in self-collected vaginal swabs

High risk, potentially cancer causing human papillomavirus infections are common among women in Papua New Guinea. But self sampling with vaginal swabs may provide materials that screen as accurately as the more labor-intensive approach using cervical samples obtained by clinicians. This finding is critical to developing same day screening and treatment, which is key to ensuring that women with precancerous lesions are treated in this largely unconnected (electronically) country, and in others like it.

Screening method uncovers drugs that may combat deadly antibiotic-resistant bacteria

BOSTON - In recent years, hospitals have reported dramatic increases in the number of cases of the highly contagious, difficult-to-treat, and often deadly antibiotic-resistant bacteria carbapenem-resistant Enterobacteriaceae (CRE). Now, investigators at Beth Israel Deaconess Medical Center (BIDMC) have developed a promising method of identifying new antimicrobials that target these organisms. The research is published in April issue of the journal ASSAY and Drug Development Technologies.

Are new therapies for Crohn's disease and chronic pancreatitis on the horizon?

Cellular and Molecular Gastroenterology and Hepatology (CMGH) is committed to publishing impactful digestive biology research covering a broad spectrum of themes in GI, hepatology and pancreatology. We wanted to share two new CMGH articles, which both offer important insight into future interventions for chronic conditions.

Functional Characterization of Inflammatory Bowel Disease -- Associated Gut Dysbiosis in Gnotobiotic Mice

By Hiroko Nagao-Kitamoto, et al.