Brain

A team of researchers at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in 30 to 40 percent of all breast cancer patients, spreading the disease, resisting traditional chemotherapies and eventually leading to death.

A new study reveals that the metadherin gene (MTDH) plays a role in both cancer metastasis and resistance to chemotherapy. The research, published by Cell Press in the January 6th issue of the journal Cancer Cell, identifies MTDH as a promising therapeutic target for high risk breast cancers.

Can The US Really Cut Health Care Spending?

WASHINGTON — Adults with diabetes experience a slowdown in several types of mental processing, which appears early in the disease and persists into old age, according to new research. Given the sharp rise in new cases of diabetes, this finding means that more adults may soon be living with mild but lasting deficits in their thought processes.

A full analysis appears in the January issue of Neuropsychology, which is published by the American Psychological Association.

Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases.

The presence of Lewy bodies suggests underlying problems in protein recycling and waste disposal, leading to the puzzle: how does disrupting those processes kill brain cells?

Westchester, Ill. — A study in the Jan. 1 issue of the journal Sleep indicates that the indirect costs of untreated insomnia are significantly greater than the direct costs associated with its treatment. The study estimates that the total annual cost of insomnia in the province of Quebec is 6.5 billion Canadian dollars, representing about one percent of the province's $228.5 billion in gross domestic product for 2002.

Waltham, Mass.—Everybody is familiar with the stereotypes of medical education from the student perspective: grueling hours, little recognition, and even less glory. Now a novel Brandeis study published in Academic Medicine this month pulls back the curtain on the dominant environment of academic medicine from the perspective of faculty, the providers of medical education in medical schools.

ST. PAUL, Minn. – A new study shows that people who are smokers and have a family history of brain aneurysm appear to be significantly more likely to suffer a stroke from a brain aneurysm themselves. The research is published in the December 31, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology and will appear in the January 6, 2009, print issue of Neurology®.

The type of stroke, called subarachnoid hemorrhage, is one of the bleeding types of stroke and is deadly in about 35 to 40 percent of people.

A team of Johns Hopkins neuroscientists has worked out how some newly discovered light sensors in the eye detect light and communicate with the brain. The report appears online this week in Nature.

These light sensors are a small number of nerve cells in the retina that contain melanopsin molecules. Unlike conventional light-sensing cells in the retina—rods and cones—melanopsin-containing cells are not used for seeing images; instead, they monitor light levels to adjust the body's clock and control constriction of the pupils in the eye, among other functions.

New computer visualization technology developed by the Harvard Initiative in Innovative Computing has helped astrophysicists understand that gravity plays a larger role than previously thought in deep space's vast, star-forming molecular clouds.

The insight, to be reported in the Jan. 1 issue of the journal Nature, is being illustrated in the journal's online version through new three-dimensional Portable Document Format (PDF) technology that will allow readers to view the article's key graphics using free PDF software already commonly found on computers.

Variants of numerous DNA repair genes initially appeared to be statistically significantly associated with cancer risk in epidemiological studies. When the data from individual studies are pooled, however, few DNA repair gene variants appear truly associated with increased cancer risk, according to a field synopsis published in the December 30 online issue of the Journal of the National Cancer Institute.

A research group lead by scientists at the University of Warwick has discovered the trigger that pulls together X chromosomes in female cells at a crucial stage of embryo development. Their discovery could also provide new insights into how other similar chromosomes spontaneously recognize each other and are bound together at key parts of analogous cell processes. This is an important mechanism as the binding togetgher of too many of too few of a particular chromosome can cause a number of medical conditions such as Down's Syndrome or Turner's Syndrome.

CORAL GABLES, FL (December 30, 2008)—Self-control is critical for success in life, and a new study by University of Miami professor of Psychology Michael McCullough finds that religious people have more self-control than do their less religious counterparts. These findings imply that religious people may be better at pursuing and achieving long-term goals that are important to them and their religious groups.

COLUMBIA, Mo. – As the need for engineering professionals grows, educators and industry leaders are increasingly concerned with how to attract women to a traditional male career. A new University of Missouri study found the impact of the engineering curriculum and obstacles, including self-efficacy and feelings of inclusion, can impede women's success in the predominantly male discipline of engineering.

"New blood" can revitalize a company or a sports team. Recent research by Tel Aviv University finds that young blood does a body good as well, especially when it comes to fighting cancer.