Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang's pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a research team from Beijing University of Chinese Medicine in China generated a sleep deprivation rat model, and orally administered Wen Dan Tang. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxiety may be a result of Wen Dan Tang's regulation of Ghrelin-Ghrelin receptors. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 2, 2014).
After 14 days of Wen Dan Tang administration, Ghrelin expression was increased in the prefrontal cortex and hypothalamus (immunohistochemistry staining).
(Photo Credit: Neural Regeneration Research)
Source: Neural Regeneration Research