The generation of new nerve cells in the brain is regulated by a peptide known as C3a, which directly affects the stem cells' maturation into nerve cells and is also important for the migration of new nerve cells through the brain tissue, reveals new research from the Sahlgrenska Academy published in the journal Stem Cells.
Although the research has been carried out using mice and cultured cells, it could lead to a new medicine for human beings, which could be given to patients who have had a stroke or other disorders that damage or destroy the nerve cells.
"Our research findings show that it could be possible to use molecules that are similar to the peptide C3a to boost the formation of nerve cells and stimulate the replacement of nerve cells lost due to injury or illness," says senior lecturer Marcela Pekna who headed the research group at theSahlgrenska Academy.
The peptide C3a is generated through the activation of the complement system, a group of proteins in the blood that is essential for the body's immune defence.
"Our research group was the first in the world to show that the complement system also plays an important role in the repair and regeneration of the brain," says Pekna. "This was a surprising discovery that opened up a whole new field of research."