Traumatic brain injury (TBI) causes gene expression changes in different brain regions. Cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor expression levels are related to the occurrence and development of TBI. However, the precise relationship between the expression levels of these three factors and neuronal injury after TBI remains poorly understood. Zhiqiang Li, Inner Mongolia Corps Hospital, Chinese People's Armed Police Forces, China performed a study and showed that sequential expression of cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor in rat hippocampal neurons was similar after fluid percussion injury, i.e., the significant expression appeared at 8 and 12 hours after injury and these three factors are involved in occurrence and development of hippocampal neuronal injury. These findings reveal the mechanism underlying hippocampal neuronal injury after TBI. These results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).
At 12 hours after fluid percussion injury, cyclooxygenase-2-positive cells (arrows) in rat hippocampal neurons were increased, as shown by immunocytochemical staining.
(Photo Credit: Neural Regeneration Research)
Source: Neural Regeneration Research