Gene regulatory network links obesity and inflammation

Posted By News On December 29, 2012 - 8:06pm

Obesity is associated with chronic inflammation, but the mechanisms that mediate this inflammation are not entirely clear. In the Journal of Clinical Investigation, researchers led by Nicolas Venteclef of the Institute of Cardiometabolism and Nutrition in Paris, identified a protein complex that blocks the expression of genes that are associated with obesity-related inflammation.

They found that the GPS2/SMRT complex was significantly reduced in fat cells from obese patients, but expression increased after gastric bypass surgery-induced weight loss, coincident with a reduction in the expression of inflammatory markers.

This study identifies a regulatory network that promotes obesity-related inflammation in humans.

TITLE: GPS2/SMRT corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation

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