PHILADELPHIA - Bringing clarity to a decades-long debate, a national team of researchers led by experts from the Perelman School of Medicine at the University of Pennsylvania has found that adding clot-busting medications known as thrombolytics to conventional approaches when treating sudden-onset pulmonary embolism patients is associated with 47 percent fewer deaths than using standard intravenous or under-the-skin anticoagulant medications alone. A pulmonary embolism is a blockage of one or more arteries in the lungs, primarily because of blood clots that travel there from the legs.
Culture
In an analysis that included data from 16 trials performed over the last 45 years, among patients with pulmonary embolism, receipt of therapy to dissolve the blood clot (thrombolysis) was associated with lower rates of death, but increased risks of major bleeding and intracranial hemorrhage, according to a study in the June 18 issue of JAMA. The authors note that these findings may not apply to patients with low-risk pulmonary embolism.
In patients with advanced uveal melanoma, treatment with the agent selumetinib, compared with chemotherapy, resulted in an improved cancer progression-free survival time and tumor response rate, but no improvement in overall survival, according to a study in the June 18 issue of JAMA. The modest improvement in clinical outcomes was accompanied by a high rate of adverse events.
The number of deaths involving commonly prescribed painkillers is higher than the number of deaths by overdose from heroin and cocaine combined, according to researchers at McGill University. In a first-of-its-kind review of existing research, the McGill team has put the spotlight on a major public health problem: the dramatic increase in deaths due to prescribed painkillers, which were involved in more than 16,000 deaths in 2010 in the U.S. alone. Currently, the US and Canada rank #1 and #2 in per capita opioid consumption.
Washington, DC—People who have hyperthyroidism are more likely to take sick leave for extended periods than their healthy colleagues, particularly in the first year after diagnosis, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Hyperthyroidism occurs when the thyroid gland is overactive. The thyroid, which is located in the front of the neck, secretes hormones that regulate how the body uses energy, consumes oxygen and produces heat.
Barriers to obtaining gene expression profiling test heightened perceived value among patients, new study saysTORONTO, June 17, 2014—Barriers to obtaining gene expression profiling tests heightened their perceived importance among patients with early breast cancer who were deciding whether to have chemotherapy, a new study says.
RIVERSIDE, Calif. — Where sustainability of water management is concerned, we must pay more attention to long-term solutions. Efficient water management and policy ought to be promoted at the local level. And a "portfolio approach" to water management is encouraged, one that includes information campaigns, different types of pricing, supply and reuse options, and technology-based rebate programs.
This news release is available in Spanish.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. It can affect various organs, in particular, the skin, joints and kidneys although it displays great variability in extent and seriousness depending on the patient. Approximately nine out of every ten patients are female and it appears in one woman in every thousand.
A tax on sweetened soft drinks could be an effective weapon in the war against obesity, generating weight losses of up to 3.64 kilograms as individuals reduce their consumption.
Researchers from Monash University, Imperial College London and University of York and Lancaster University, England have estimated the extent to which drinking habits would change if beverages such as carbonated non-diet soft drinks; cordials and fruit drinks were taxed.
A study in the July issue of Anesthesiology revealed that patients who receive a simple, multicolor, standardized medication instruction sheet before surgery are more likely to comply with their physician's instructions and experience a significantly shorter post-op stay in recovery.
A debilitating syndrome that causes an excessively rapid heartbeat on standing up, predominantly affects young well educated women, and blights their lives, because it is so poorly understood and inconsistently treated, reveals a small study published in the online journal BMJ Open.
Postural tachycardia syndrome, or PoTS for short, is a by-product of orthostatic intolerance - a disorder of the autonomic nervous system in which the circulatory and nervous system responses needed to compensate for the stress put on the body on standing upright, don't work properly.
Stroke risk in women begins in young adulthood, according to a guideline synopsis being published in Annals of Internal Medicine. While stroke typically affects women in old age, sex-specific guidelines from the American Heart Association and American Stroke Association recommend that physicians assess a woman's health history for unique events that increase her risk of stroke later in life, such as being diagnosed with preeclampsia or using of hormonal contraceptives.
Boston, MA — A new poll by The Boston Globe and Harvard School of Public Health (HSPH) finds, eight years into the state's universal health insurance legislation enacted in 2006, 63% of Massachusetts residents support the law and 18% oppose it, while 7% are not sure, and 12% have not heard or read about the law. The percentage of residents supporting the law remains unchanged since a 2011 Boston Globe/HSPH poll. Support for the law varies by party affiliation, with 77% of Democrats, 60% of Independents, and 49% of Republicans saying they support the legislation.
Bottom Line: Use of beta (β)-blockers in patients who have not had a recent heart attack but were undergoing nonemergency coronary artery bypass grafting (CABG) surgery was not associated with better outcomes.
Author: William Brinkman, M.D., of the Cardiopulmonary Research Science and Technology Institute, Dallas, and colleagues.
Background: The use of preoperative β-blockers has been associated with a reduction in perioperative mortality for patients undergoing CABG surgery in previous observational studies. Preoperative β-blocker therapy is a national quality standard.
Bottom Line: A multipart intervention increased adherence rates of annual fecal occult blood testing (FOBT) for colorectal cancer (CRC) screening in vulnerable populations.
Author: David W. Baker, M.D., M.P.H., of the Feinberg School of Medicine at Northwestern University, Chicago, and colleagues.