Are we closer to understanding the cause of deadly sepsis?

Posted By News On November 16, 2012 - 4:00pm
Are we closer to understanding the cause of deadly sepsis?

New Rochelle, NY, November 13, 2012—Following an infection, dysregulation of the immune system can result in a systemic inflammatory response and an often fatal condition called severe sepsis or septic shock. Sepsis is not uncommon, yet its cause and underlying immune dysfunction remain poorly understood. Regulatory T cells (Tregs), a component of the immune system, now appear to have an important role in suppressing the immune response in advance of sepsis, and understanding this role may lead to new therapeutic strategies for improving patient outcomes, as described in a review article in Journal of Interferon & Cytokine Research, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free online on the Journal of Interferon & Cytokine Research website.

Li-Na Jiang, Yong-Ming Yao, and Zhi-Yong Sheng, Chinese PLA General Hospital, Beijing, and Hebei North University, Zhyangjiakou, China, review the growing body of literature supporting a link between alterations in Treg function and the development of sepsis, based on animal studies and preliminary human studies. In the article "The Role of Regulatory T Cells in the Pathogenesis of Sepsis and Its Clinical Implications (http://online.liebertpub.com/doi/full/10.1089/jir.2011.0080)," the authors suggest that accumulating experimental and clinical evidence indicates that manipulating Tregs may offer a promising strategy for treating patients with septic shock.

Journal of Interferon & Cytokine Research, led by Co-Editors-in-Chief Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation, and Thomas A. Hamilton, PhD, is an authoritative peer-reviewed journal published monthly in print and online that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is the official journal of the International Society for Interferon and Cytokine Research. Complete tables of content and a sample issue may be viewed online on the Journal of Interferon & Cytokine Research website.

(Photo Credit: © Mary Ann Liebert, Inc., publishers)

"Regulatory T cells are receiving much attention as important determinants of both beneficial and detrimental immune responses," says Co-Editor-in-Chief Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation. "This review brings focus to the function of this important cell population in the context of sepsis, a condition more frequently associated with innate immunity."

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