25 percent of people who look obese are metabolically healthy and don't have a high risk of developing type 2 diabetes, even though obesity is a major risk factor for diabetes.
A study finds a possible explanation, revealing that high levels of a molecule called heme oxygenase-1 (HO-1) are linked to poor metabolic health and an increased risk of type 2 diabetes in obese humans. Moreover, HO-1 inhibition improves metabolic health in obese mice, suggesting that HO-1 blockers could represent a promising new strategy for the treatment of metabolic disease.
The body contains two types of fat cells, white and brown.
White fat serves to store excess calories until they're needed by the body while brown adipocytes actually burn fat by turning it into heat. Ever since it was discovered that adult humans harbor appreciable amounts of brown fat, investigators have been working to better understand its thermogenic fat-burning properties with the ultimate goal of developing novel therapies to combat obesity and diabetes.
Now, researchers have demonstrated that the transcription factor IRF4 (interferon regulatory factor 4) plays a key role in brown fat's thermogenic process, regulating energy expenditure and cold tolerance.
Many ancient plants weren't pretty, they didn't taste good, and they weren't big - but they could defend themselves.
As food science progressed, numerous plants were genetically optimized for better flavor and yield, but some lost their ability to produce certain defense chemicals, making them vulnerable to attack by insects and pathogens. Swiss scientists are exploring ways to help protect 21st century maize by re-arming it with its ancestral chemical weapons.
For hibernating mammals, the pre-winter months are a race to accumulate enough energy reserves to last until spring.
But what about offspring born late in the year? They have less time to store energy. Austrian scientists have discovered that power-napping can help late-born dormice overcome these unfavorable odds.
Taking the street drug Ecstasy could lead to a potentially fatal weakening and rupture of the spinal cord artery, according to a new paper.
Posterior spinal artery aneurysms - a blood-filled swelling of the spinal cord artery, caused by a weakening and distension of the vessel wall - are rare, with only 12 cases reported to date. But all of them caused spinal bleeding which affected the function of the spinal cord.
When NASA's Aqua satellite passed over Tropical Storm Arthur on July 2 at 2:50 PM EDT on July 2nd, it saw a cloud-covered eye as the storm was on the way to becoming a hurricane.
This visible image of Tropical Storm Arthur was captured by the Moderate Resolution Imaging Spectroradiometer or MODIS instrument that flies aboard NASA's Aqua satellite. Arthur's center was over the Atlantic Ocean and east of Florida's northeast coast.
By 5 AM EDT on July 3, Arthur's eye had formed but remained cloud covered even as the storm hit hurricane-strength with maximum sustained winds near 75 MPH.
Though strange fads like the blood type diet, going gluten-free or going vegetarian are clearly gimmicks, when your body is in a rut, it helps to change it up a little.
Just like exercise, if you do the same workout every day, its effectiveness will drop - and eating pasta and vegetables all of the time will make it hard to lose weight. But if that is your diet, forget counting calories and just eat meat. Your body will take care of the rest. Don't live the rest of your life that way, that is as crazy as being vegetarian, but for weight loss, it's better to count macronutrients than calories.
Motörhead concert goers may have to sign a waiver before they buy tickets. If that band were in California, they would have to wear a Proposition 65 warning on their shirts.
Why? Because they can give you brain damage, according to a Case Report published in The Lancet. Ariyan Pirayesh Islamian and colleagues from the Hannover Medical School, detail the case of a man who developed a chronic subdural hematoma (bleeding in the brain) after headbanging at a Motörhead concert.
In Switzerland, 7,000 to 8,000 persons each year fall ill with a campylobacter infection, making it the most frequent bacterial disease transmitted through food.
Many traits unique to humans are thought to have originated in the genus Homo between 2.4 and 1.8 million years ago in Africa.
What are the evolutionary factors that drove them?
A large brain, long legs, the ability to craft tools and prolonged maturation periods were all thought to have evolved together at the start of the Homo lineage as African grasslands expanded and Earth's climate became cooler and drier. However, new climate and fossil evidence analyzed by a team of researchers suggests that these traits did not arise as a single package. Rather, several key ingredients once thought to define Homo evolved in earlier Australopithecus ancestors between 3 and 4 million years ago, while others emerged significantly later.
Researchers have announced the discovery of a gene, zic-1, that enables stem cells to regrow a head after decapitation in flatworm planarians.
The earthquakes in central Oklahoma since 2009 are likely attributable to subsurface wastewater injection at a handful of disposal wells -
Oklahoma earthquakes constitute nearly half of all central and eastern U.S. seismicity from 2008 to 2013, many occurring in areas of high-rate water disposal.
These are legacy drilling operations, not modern natural gas fracking.
The reduction of soil carbon stock caused by the conversion of pasture areas into sugarcane plantations is very common change in Brazil in recent years but those worried about the impact on CO2 can rest easy. It can be offset within two or three years of cultivation.
The calculation by researchers at the Center for Nuclear Energy in Agriculture (CENA) of the University of São Paulo (USP) in collaboration with colleagues from the Luiz de Queiroz College of Agriculture (Esalq), also at USP, concluded, "Soil carbon stocks on land-use change process to sugarcane production in South-Central Brazil."
Acoustic vibrations – sound waves – are produced by radiation pressure inside stars. While physicists have long posited that young stars vibrate differently than older stars, a new study says it is the first to confirm these predications using concrete data from outer space.
First author Konstanze Zwintz, a postdoctoral researcher at KU Leuven's Institute for Astronomy, and her colleagues studied the vibrations of 34 stars aged under 10 million years and sized between one and four times the mass of our sun.
The FDA released its long-awaited Draft Guidance on hospital-acquired pneumonia recently. Their guidance has not changed since I wrote a blog about my last meeting with the FDA antibacterial drug development task force back in September of last year.
To reiterate what I stated back then . . .