In its first clinical trial, an antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, investigators at Dana-Farber Cancer Institute and other organizations have reported.
The drug, daratumumab, proved generally safe in patients, even at the highest doses tested in the study. The results of the trial - a combined phase 1 and 2 study - strongly support testing of the drug in a larger group of patients in both phase 2 and 3 trials, the authors say.
Following one of the largest-scale scientific reproducibility investigations to date, a group of psychology researchers has reported results from an effort to replicate 100 recently published psychology studies; though they were able to successfully repeat the original experiments in most all cases, they were able to reproduce the original results in less than half, they report.
Male teens who experiment with cannabis before age 16, and have a high genetic risk for schizophrenia, show a different brain development trajectory than low risk peers who use cannabis.
The discovery, made from a combined analysis of over 1,500 youth, contributes to a growing body of evidence implicating cannabis use in adolescence and schizophrenia later in life.
"If I offered you a bruised banana, you probably wouldn't be interested," said Jonathan Deutsch, PhD, director of Drexel University's Center for Hospitality and Sport Management. "But what if I offered you some banana ice cream on a hot summer day? I bet you'd find that a lot more appealing."
It was this simple observation that inspired a new model for recovering would-be wasted - or surplus - food and repurposing it to feed hungry people, generate revenue and even create jobs. The model was recently piloted in West Philadelphia, home to a large population of low-income and food insecure individuals, as part of the Environmental Protection Agency's Food Recovery Challenge with support from Brown's Super Stores.
This is just for fun. At first sight this seems impossible - the smallest stars are heavier than the heaviest planets, and how can something heavier orbit something that is lighter? But what if you have a very dense star and very large very low density planet? And if you interpret "orbiting it" as "having barycenter (the "center of mass of the system") within the planet"?
Also, could a star sometimes be lighter than a planet, is that possible at all? I'll also describe a way that a heavier object can, in a way, "orbit" a lighter one - a way to get a heavier star move in such a way that the barycenter of the system lies within a large low density planet - can you figure out how, before I get to it?-->
Thanks to decades of action against tobacco, smoking rates among children and young people are in decline: far fewer teenagers are now taking up smoking than in the past.
A new study clearly establishes a partial genetic basis underlying racial differences in slow-wave sleep, suggesting that it may be possible to develop sleep-related therapies that target specific genetic variants.
Using a panel of 1,698 ancestry informative genetic markers, the study found that greater African genetic ancestry was associated with lower amounts of slow-wave sleep in African-American adults. African ancestry explained 11 percent of the variation in slow-wave sleep after adjustment for potential confounders. Although a similar association was observed for delta power, no association with African ancestry was observed for sleep duration and efficiency.
The War on Fast Food hasn't led to the health care bonanza overzealous regulators assured us would result - but that hasn’t stopped them from opening another front on Happy Meals.
A scientist name Kevin Folta at the University of Florida has been one of a broader group of public researchers who have come under hostile, Freedom Of Information Act scrutiny with the goal of demonstrating “ties to industry.”
Why do unmarried women tend to be more liberal and Democratic than their married counterparts? A key reason is because unmarried women -- those who have never been married and those who are divorced -- are more concerned about the status of women as a collective group according to survey results presented at the 110th Annual Meeting of the American Sociological Association.
More than a quarter of a million people die each year that are linked to using smokeless tobacco, say scholars who believe that governments need to consider incorporating the regulation of smokeless tobacco into policy frameworks.
A paper funded by Leeds City Council and the Medical Research Council links smokeless tobacco to more than 62,000 deaths due to cancers of the mouth, pharynx and oesophagus and accounted for more than 200,00 deaths from heart disease in 2010.
New research could potentially yield a new platform for cancer vaccines. Leveraging a biologically inspired sponge-like gel called "cryogel" as an injectable biomaterial, the vaccine delivers patient-specific tumor cells together with immune-stimulating biomolecules to enhance the body's attack againstcancer. The approach, a so-called "injectable cryogel whole-cell cancer vaccine."
David Mooney, Ph.D., leads a Wyss Institute team developing a broad suite of novel cancer vaccines and immunotherapies.
Licensed tobacco retailers throughout New York City are selling a substantial number of cigarette packs carrying either counterfeit or out-of-state tax stamps, finds an investigation by NYU public health researchers.
These illegal cigarette sales are more pervasive in independent stores, as opposed to chain stores.
Lecithin is an ingredient that you've probably never heard of, but one that plays a vital role in the production of chocolate and many other foods. It's never been clear how this ingredient works on a molecular level, and confectioners have relied on observational methods - essentially trial and error - to perfect their recipes.
Now, scientists have shown how the field of molecular dynamics (simulation on a molecular level) could be a valuable tool in understanding chocolate conching - the part of the chocolate-making process where aromatic sensation, texture and 'mouthfeel' are developed.
New research predicts that Earth has more than 1,500 undiscovered minerals and that the exact mineral diversity of our planet is unique and could not be duplicated anywhere in the cosmos. Minerals form from novel combinations of elements. These combinations can be facilitated by both geological activity, including volcanoes, plate tectonics, and water-rock interactions, and biological activity, such as chemical reactions with oxygen and organic material.
But what are the facts behind these entertaining fictions? And how best to dispel the myths and misconceptions perpetuated by blockbuster films while also enlightening audiences on the real marvels of biotechnology?-->
One in five older people who drink alcohol are consuming it at unsafe levels - over 21 units of alcohol for men and 14 units for women each week - according to a study by King's College London. The research in inner-city London, published in BMJ Open, found these unsafe older drinkers are more likely to be of higher socioeconomic status.
The researchers used anonymised electronic GP health records for 27,991 people aged 65 and over in the Borough of Lambeth in London. From these records, they identified 9,248 older people who had reported consuming alcohol and of these 1,980 people drank at unsafe levels.
African women in polygamous marriages or with alcoholic husbands have a significantly higher risk of being physically abused by their husbands than women in monogamous marriages or women whose husbands don't abuse alcohol, according to survey results presented at the 110th Annual Meeting of the American Sociological Association.