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Gene Therapy For Cystic Fibrosis Shows Beneficial Effect On Lung Function

Science2.0 - July 3, 2015 - 10:14am

For the first time gene therapy for cystic fibrosis has shown a significant benefit in lung function compared with placebo, in a phase 2 randomized trial. The technique replaces the defective gene response for cystic fibrosis by using inhaled molecules of DNA to deliver a normal working copy of the gene to lung cells.

“Patients who received the gene therapy showed a significant, if modest, benefit in tests of lung function compared with the placebo group and there were no safety concerns,” said senior author Professor Eric Alton from the National Heart and Lung Institute at Imperial College London. “Whilst the effect was inconsistent, with some patients responding better than others, the results are encouraging.”


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Categories: Science2.0

Gene Therapy For Cystic Fibrosis Shows Beneficial Effect On Lung Function

General - July 3, 2015 - 10:14am

For the first time gene therapy for cystic fibrosis has shown a significant benefit in lung function compared with placebo, in a phase 2 randomized trial. The technique replaces the defective gene response for cystic fibrosis by using inhaled molecules of DNA to deliver a normal working copy of the gene to lung cells.

“Patients who received the gene therapy showed a significant, if modest, benefit in tests of lung function compared with the placebo group and there were no safety concerns,” said senior author Professor Eric Alton from the National Heart and Lung Institute at Imperial College London. “Whilst the effect was inconsistent, with some patients responding better than others, the results are encouraging.”


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Categories: News

Mammoth Clones Are Coming

RealClearScience - July 3, 2015 - 5:30am
Categories: RealClearScience

The 'Speed of Thought'

RealClearScience - July 3, 2015 - 5:30am
Categories: RealClearScience

3 Elements Not Made in Stars

RealClearScience - July 3, 2015 - 5:30am
Categories: RealClearScience

You Are A Citizen Scientist Researcher In The Genetic Arms Race Between Humans And Mosquitoes

Science2.0 - July 2, 2015 - 3:30pm

Every time you put on bug spray this summer, you're another front in the ongoing war between humans and mosquitoes - and being a citizen scientist in a complex evolutionary experiment.

Scientists have found that between 5 and 20 percent of a mosquito population's genome is subject to evolutionary pressures at any given time, creating a strong signature of local adaptation to environment and humans. This means that individual populations are likely to have evolved resistance to whatever local selection pressures are typical in their area, and that understanding the genomes of those populations could one day help inform agencies about which pesticides are likely to be most effective against them.


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Categories: Science2.0

You Are A Citizen Scientist Researcher In The Genetic Arms Race Between Humans And Mosquitoes

General - July 2, 2015 - 3:30pm

Every time you put on bug spray this summer, you're another front in the ongoing war between humans and mosquitoes - and being a citizen scientist in a complex evolutionary experiment.

Scientists have found that between 5 and 20 percent of a mosquito population's genome is subject to evolutionary pressures at any given time, creating a strong signature of local adaptation to environment and humans. This means that individual populations are likely to have evolved resistance to whatever local selection pressures are typical in their area, and that understanding the genomes of those populations could one day help inform agencies about which pesticides are likely to be most effective against them.


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Categories: News

A Single Mutation Helped Last Year's Flu Virus Gain An Advantage Over The Vaccine

General - July 2, 2015 - 3:14pm

The 2014-2015 flu vaccine didn't work as well compared to previous years because the H3N2 virus recently acquired a mutation that concealed the infection from the immune system. A study published on June 25 in Cell Reports reveals the major viral mutation responsible for the mismatch between the vaccine strain and circulating strains. The research will help guide the selection of viral strains for future seasonal flu vaccines.


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Categories: News

A Single Mutation Helped Last Year's Flu Virus Gain An Advantage Over The Vaccine

Science2.0 - July 2, 2015 - 3:14pm

The 2014-2015 flu vaccine didn't work as well compared to previous years because the H3N2 virus recently acquired a mutation that concealed the infection from the immune system. A study published on June 25 in Cell Reports reveals the major viral mutation responsible for the mismatch between the vaccine strain and circulating strains. The research will help guide the selection of viral strains for future seasonal flu vaccines.


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Categories: Science2.0

Attractive Females Harmed By Male Sexual Harassment

Science2.0 - July 2, 2015 - 2:00pm

Too much male sexual attention harms attractive females, according to a new Australian and Canadian study on fruit flies.

Associate Professor Steve Chenoweth from The University of Queensland's School of Biological Sciences said the study showed that male harassment of females hampered the species' ability to adapt to new environmental conditions.

"We found that sexually attractive females were overwhelmed by male suitors," he said.

"Female fruit flies with superior genes that allow them to lay more eggs were so attractive to male suitors they spent most of the time fending off male suitors rather than actually laying eggs. The end result was that these supposedly 'superior' genes could not be passed on to the next generation."


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Categories: Science2.0

Attractive Females Harmed By Male Sexual Harassment

General - July 2, 2015 - 2:00pm

Too much male sexual attention harms attractive females, according to a new Australian and Canadian study on fruit flies.

Associate Professor Steve Chenoweth from The University of Queensland's School of Biological Sciences said the study showed that male harassment of females hampered the species' ability to adapt to new environmental conditions.

"We found that sexually attractive females were overwhelmed by male suitors," he said.

"Female fruit flies with superior genes that allow them to lay more eggs were so attractive to male suitors they spent most of the time fending off male suitors rather than actually laying eggs. The end result was that these supposedly 'superior' genes could not be passed on to the next generation."


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Categories: News

Is Abortion In America About To Get Restricted?

Science2.0 - July 2, 2015 - 1:30pm

The Supreme Court seems poised to take on the abortion issue again, and with reason.

On June 29, by a five-to-four vote, the Court temporarily blocked a Texas law that would force many clinics to close, guaranteeing that the state’s new law would not take effect until the justices decide whether to rule on its constitutionality. And just today, June 30, the Court did not take action on a case involving a similar abortion restriction passed in Mississippi.


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Categories: Science2.0

Is Abortion In America About To Get Restricted?

General - July 2, 2015 - 1:30pm

The Supreme Court seems poised to take on the abortion issue again, and with reason.

On June 29, by a five-to-four vote, the Court temporarily blocked a Texas law that would force many clinics to close, guaranteeing that the state’s new law would not take effect until the justices decide whether to rule on its constitutionality. And just today, June 30, the Court did not take action on a case involving a similar abortion restriction passed in Mississippi.


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Categories: News

First Species Of Yeti Crab Found In Antarctica

Science2.0 - July 2, 2015 - 12:51pm

The first species of Yeti Crab from hydrothermal vent systems of the East Scotia Ridge in the Southern Ocean, Antarctica, has been described in a study by Sven Thatje from University of Southampton, and colleagues.

The species of Yeti crab Kiwa tyleri belongs to an enigmatic group of squat lobsters, known as Kiwaidae, that thrive in the hot waters surrounding the geothermally heated hydrothermal vents. It is the dominant species at these sites, occurring at extremely high densities exceeding 700 specimens per square meter.


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Categories: Science2.0

First Species Of Yeti Crab Found In Antarctica

General - July 2, 2015 - 12:51pm

The first species of Yeti Crab from hydrothermal vent systems of the East Scotia Ridge in the Southern Ocean, Antarctica, has been described in a study by Sven Thatje from University of Southampton, and colleagues.

The species of Yeti crab Kiwa tyleri belongs to an enigmatic group of squat lobsters, known as Kiwaidae, that thrive in the hot waters surrounding the geothermally heated hydrothermal vents. It is the dominant species at these sites, occurring at extremely high densities exceeding 700 specimens per square meter.


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Categories: News

Medial Temporal Lobe And How New Memories Are Formed

Science2.0 - July 2, 2015 - 12:46pm

In a new study, researchers found that neurons in a specific brain region play a key role in rapidly forming memories about every day events, a finding that may result in a better understanding of memory loss and new methods to fight it in Alzheimer’s and other neurological diseases.

Specifically, the study examined neurons in the medial temporal lobe associated with episodic memory, the brain’s ability to consciously recall experienced events and situations like running into an old school friend at the opera. Episodic memory logs these unique experiences and relies on the very rapid formation of new associations in the brain.


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Categories: Science2.0

Medial Temporal Lobe And How New Memories Are Formed

General - July 2, 2015 - 12:46pm

In a new study, researchers found that neurons in a specific brain region play a key role in rapidly forming memories about every day events, a finding that may result in a better understanding of memory loss and new methods to fight it in Alzheimer’s and other neurological diseases.

Specifically, the study examined neurons in the medial temporal lobe associated with episodic memory, the brain’s ability to consciously recall experienced events and situations like running into an old school friend at the opera. Episodic memory logs these unique experiences and relies on the very rapid formation of new associations in the brain.


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Categories: News

What May Be Missing From Quantum Computing - A Quantum Middle Man

Science2.0 - July 2, 2015 - 11:16am
Quantum computing is well into its second decade of hype with little progress being made. Computer chip companies have continued to optimize available physics and have left the quantum kind to the academic sandbox. It's not stable long enough to make calculations.

Perhaps what is needed is an intermediary to transmit information, say researchers at the Okinawa Institute of Science and Technology Graduate University (OIST).
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Categories: Science2.0

What May Be Missing From Quantum Computing - A Quantum Middle Man

General - July 2, 2015 - 11:16am
Quantum computing is well into its second decade of hype with little progress being made. Computer chip companies have continued to optimize available physics and have left the quantum kind to the academic sandbox. It's not stable long enough to make calculations.

Perhaps what is needed is an intermediary to transmit information, say researchers at the Okinawa Institute of Science and Technology Graduate University (OIST).
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Categories: News